Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment

Apollinariya A. Volokhova, Valeriya L. Kudryavtseva, Tatiana I. Spiridonova, Ilya Kolesnik, Semen I. Goreninskii, Roman V. Sazonov, Gennady E. Remnev, Sergei I. Tverdokhlebov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Currently, electrospun synthetic bioresorbable polymer scaffolds are applied in regenerative medicine and tissue engineering as targeted drug delivery devices because of their mechanical and physico-chemical properties. To control the rate of polymer degradation and drug release from polymer scaffolds, surface modification techniques are widely used. In this study, paracetamol-loaded poly (ε-caprolactone) electrospun fibrous scaffolds were treated by the pulsed electron beam irradiation. Pure control PCL scaffold, as well as scaffolds with four paracetamol concentrations (2 wt./wt. %, 8 wt./wt. %, 16 wt./wt. %, and 32 wt./wt.%) were modified. The mechanical and chemical properties and morphology of modified materials were examined. The sustained release of the model drug over a period of one hour for both non-treated and treated samples was demonstrated. It was shown that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution.

Original languageEnglish
Article number102134
JournalMaterials Today Communications
Volume26
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Biodegradable materials
  • Drug delivery devices
  • Electron beam treatment
  • Electrospinning
  • Polycaprolactone

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment'. Together they form a unique fingerprint.

Cite this