Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro

Sujit Kootala, Yu Zhang, Sara Ghalib, Vladimir Tolmachev, Jöns Hilborn, Dmitri A. Ossipov

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Original languageEnglish
Pages (from-to)250-254
Number of pages5
JournalBiomaterials Science
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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