Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

Abstract

A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

Original language	English
Pages (from-to)	39
Number of pages	1
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	60
Issue number	1
Publication status	Published - 1997

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea",

abstract = "A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.",

author = "Maimeskulova, {L. A.} and Maslov, {L. N.} and Lishmanov, {Yu B.} and Krasnov, {E. A.}",

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AU - Maimeskulova, L. A.

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Krasnov, E. A.

PY - 1997

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N2 - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

AB - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

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Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

Abstract

ASJC Scopus subject areas

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