Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

Abstract

A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

Original language	English
Pages (from-to)	39
Number of pages	1
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	60
Issue number	1
Publication status	Published - 1997

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea'. Together they form a unique fingerprint.

Cite this

@article{5db8523af9b34c6d863b82aaeba84927,

title = "Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea",

abstract = "A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.",

author = "Maimeskulova, {L. A.} and Maslov, {L. N.} and Lishmanov, {Yu B.} and Krasnov, {E. A.}",

year = "1997",

language = "English",

volume = "60",

pages = "39",

journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",

issn = "0869-2092",

publisher = "Izdatelstvo Meditsina",

number = "1",

}

TY - JOUR

T1 - Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

AU - Maimeskulova, L. A.

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Krasnov, E. A.

PY - 1997

Y1 - 1997

N2 - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

AB - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

UR - http://www.scopus.com/inward/record.url?scp=0347803617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347803617&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0347803617

VL - 60

SP - 39

JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

SN - 0869-2092

IS - 1

ER -