Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

L. A. Maimeskulova, L. N. Maslov, Yu B. Lishmanov, E. A. Krasnov

Research output: Contribution to journalArticle

Abstract

A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

Original languageEnglish
Pages (from-to)39
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume60
Issue number1
Publication statusPublished - 1997

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Rhodiola
Opioid Receptors
Naloxone
Epinephrine
Opioid Analgesics
Rats
Cardiac Arrhythmias
Chemical activation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea. / Maimeskulova, L. A.; Maslov, L. N.; Lishmanov, Yu B.; Krasnov, E. A.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 60, No. 1, 1997, p. 39.

Research output: Contribution to journalArticle

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