Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea

L. A. Maimeskulova, L. N. Maslov, Yu B. Lishmanov, E. A. Krasnov

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Abstract

A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.

Original languageEnglish
Pages (from-to)39
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume60
Issue number1
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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