Abstract
A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.
| Original language | English |
|---|---|
| Pages (from-to) | 39 |
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 60 |
| Issue number | 1 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea. / Maimeskulova, L. A.; Maslov, L. N.; Lishmanov, Yu B.; Krasnov, E. A.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 60, No. 1, 1997, p. 39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contribution of μ-, δ-, and κ-opioid receptors to realization of the antiarrhythmic effect of rhodiola rosea
AU - Maimeskulova, L. A.
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
AU - Krasnov, E. A.
PY - 1997
Y1 - 1997
N2 - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.
AB - A course of the adaptogen Extractus Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of μ-opiate receptors (OR) by naloxone (0.2 mg/kg) and δ-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of Extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of κ-OR.
UR - http://www.scopus.com/inward/record.url?scp=0347803617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347803617&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0347803617
VL - 60
SP - 39
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 1
ER -