Sokratitel'nye reaktsii gladkikh myshts vozdukhonosnykh putei pri éksperimental'noi astme: rol' interleikina-5 v formirovanii giperreaktivnosti bronkhov.

Translated title of the contribution: Contractile responses of the airways smooth muscles in experimental bronchial asthma; the role of interleukin 5 in formation of hyper-responsiveness of bronchial tubes

L. V. Kapilevich, L. M. Ogorodova, A. é Sazonov, E. I. D'iakova, I. S. Popova, A. V. Nosarev, T. N. Zaǐtseva

Research output: Contribution to journalArticlepeer-review

Abstract

By mehanographic method, contraktile responses of the airways smooth muscles in experimental bronchial asthma in porpoises intact and incubated with interleykin-5, were studied. Sensitization of ovalbumin animals results in development of hypersensitivity to inhalation of the fiber with external attributes of infringement of bronchial passableness such as cough and a shortness of breath. Morphologically the process is accompanied by destruction of epithelium of the bronchial tubes, development of an immune inflammation in a bronchial wall, and a hypertrophy of the muscular layer. In the sensitized animals, development of hyper-responsiveness of the airways smooth muscles to histamine was obvious as shown in a significant decrease of the threshold concentration and an increase in the maximal amplitude of reduction. Interleukin-5 was shown to strengthen this process. Responses to holinergic and R2-adrenerdic influences practically did not change. The data obtained corroborate the hypothesis of development of the interleukin-5-depending bronchial hyper-responsiveness in absence of eosinophile damage in the mucous membrane of the bronchial tubes.

Translated title of the contributionContractile responses of the airways smooth muscles in experimental bronchial asthma; the role of interleukin 5 in formation of hyper-responsiveness of bronchial tubes
Original languageRussian
Pages (from-to)1262-1269
Number of pages8
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume90
Issue number10
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Medicine(all)

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