Abstract
In experiments on white Wistar rats the effect of acute 4-hour freezing at -10 °C on contractile function of the hearts isolated by the Langendorff technique, and the protective efficacy of Rhodiolae Rosea extractum were investigated. The obtained results testify to the fact that acute cooling leads to a decrease in myocardial contractile activity that recovers during 18 hours. But this recovery cannot be complete as it does not result in stable contractility of isolated heart in perfusion. Preliminary adaptation of animals during treatment with Rhodiolae Rosea extract prevents the decrease in contractility force immediately after acute cooling and contributes to the stable contractility during 60 minutes of perfusion. Moreover, Rhodiolae Rosea extract does not remove the disturbance in diastolic function and in all cases leads to a decrease in coronary blood flow. The effect of Rhodiolae Rosea extract on the myocardium is likely to be similar to that of myocardial recovery after acute cooling.
| Original language | English |
|---|---|
| Pages (from-to) | 480-483 |
| Number of pages | 4 |
| Journal | Byulleten Eksperimentalnoi Biologii i Meditsiny |
| Volume | 116 |
| Issue number | 11 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Contractile function of the heart after acute cooling and its correction by adaptogens. / Afanasyev, S. A.; Alekseeva, E. D.; Bardamova, I. B.; Maslova, L. V.; Lishmanov Yu., B.
In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 116, No. 11, 1993, p. 480-483.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Contractile function of the heart after acute cooling and its correction by adaptogens
AU - Afanasyev, S. A.
AU - Alekseeva, E. D.
AU - Bardamova, I. B.
AU - Maslova, L. V.
AU - Lishmanov Yu., B.
PY - 1993
Y1 - 1993
N2 - In experiments on white Wistar rats the effect of acute 4-hour freezing at -10 °C on contractile function of the hearts isolated by the Langendorff technique, and the protective efficacy of Rhodiolae Rosea extractum were investigated. The obtained results testify to the fact that acute cooling leads to a decrease in myocardial contractile activity that recovers during 18 hours. But this recovery cannot be complete as it does not result in stable contractility of isolated heart in perfusion. Preliminary adaptation of animals during treatment with Rhodiolae Rosea extract prevents the decrease in contractility force immediately after acute cooling and contributes to the stable contractility during 60 minutes of perfusion. Moreover, Rhodiolae Rosea extract does not remove the disturbance in diastolic function and in all cases leads to a decrease in coronary blood flow. The effect of Rhodiolae Rosea extract on the myocardium is likely to be similar to that of myocardial recovery after acute cooling.
AB - In experiments on white Wistar rats the effect of acute 4-hour freezing at -10 °C on contractile function of the hearts isolated by the Langendorff technique, and the protective efficacy of Rhodiolae Rosea extractum were investigated. The obtained results testify to the fact that acute cooling leads to a decrease in myocardial contractile activity that recovers during 18 hours. But this recovery cannot be complete as it does not result in stable contractility of isolated heart in perfusion. Preliminary adaptation of animals during treatment with Rhodiolae Rosea extract prevents the decrease in contractility force immediately after acute cooling and contributes to the stable contractility during 60 minutes of perfusion. Moreover, Rhodiolae Rosea extract does not remove the disturbance in diastolic function and in all cases leads to a decrease in coronary blood flow. The effect of Rhodiolae Rosea extract on the myocardium is likely to be similar to that of myocardial recovery after acute cooling.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027687449&partnerID=8YFLogxK
M3 - Article
C2 - 8312534
AN - SCOPUS:0027687449
VL - 116
SP - 480
EP - 483
JO - Byulleten Eksperimentalnoi Biologii i Meditsiny
JF - Byulleten Eksperimentalnoi Biologii i Meditsiny
SN - 0365-9615
IS - 11
ER -