Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age

O. Yu Fedorenko, N. A. Bokhan, S. A. Ivanova

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.

Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume154
Issue number1
DOIs
Publication statusPublished - Nov 2012

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Keywords

  • age features
  • conformational stability
  • lactate dehydrogenase
  • leukocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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