Concentration of toxins in endosomal compartment of the cells pretreated with ricin and viscumin

Sh Yu Khapchaev, S. S. Gutor, I. P. Kaminskii, E. E. Kremer, S. V. Krivoshchekov, I. V. Mil'to, Alexandra Gennadievna Pershina, I. V. Petrova, I. V. Saltykova, N. S. Subbotina, K. V. Khvorilova

Research output: Contribution to journalArticle

Abstract

Data on volume of the intracellular compartment where the internalized toxin is located and toxin concentration in this compartment have been obtained. Suggestions have been made about a role of toxin molecule aggregates in the translocation of A-chain into cytosol, which leads to cell death.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalMoscow University Biological Sciences Bulletin
Volume68
Issue number4
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • confocal microscopy
  • monoclonal antibodies
  • ricin
  • viscumin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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    Khapchaev, S. Y., Gutor, S. S., Kaminskii, I. P., Kremer, E. E., Krivoshchekov, S. V., Mil'to, I. V., Pershina, A. G., Petrova, I. V., Saltykova, I. V., Subbotina, N. S., & Khvorilova, K. V. (2013). Concentration of toxins in endosomal compartment of the cells pretreated with ricin and viscumin. Moscow University Biological Sciences Bulletin, 68(4), 174-177. https://doi.org/10.3103/S0096392514010040