Abstract
Electrospun biodegradable scaffolds (matrixes) made of poly(ϵ-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are three-dimensional fibrous structures that are commonly used in regenerative medicine and drug delivery systems. Modification of such structures allows manipulating with biological and immune response. Previously, our team suggested a number of surface modification strategies for thin films made of PLLA. One of the proposed strategies are based on treatment of the material with "solvent/non-solvent" mixture that allows absorbing biologically active molecules or linkers on the surface of the sample. The aim of this work was to compare the influence of "solvent/non-solvent" treatment on the structure and crystallinity of the elecrospun biodegradable PCL and PLLA scaffolds. For that purpose, original PCL and PLLA scaffolds were treated with mixture of toluene and ethanol in different proportions. Morphology of the obtained samples was studied using scanning electron microscopy. It was shown that "solvent/non-solvent" treatment doesn't lead to changes in scaffolds morphology such as gluing or cutting of the matrix fibers. By means of X-ray diffraction analysis it was shown that treatment of the samples with selected mixtures doesn't change material crystallinity. Thus, it was demonstrated that proposed composition of the "solvent/nonsolvent" mixture can be used for the modification of electrospun PCL and PLLA scaffolds.
| Original language | English |
|---|---|
| Article number | 01025 |
| Journal | MATEC Web of Conferences |
| Volume | 79 |
| DOIs | |
| Publication status | Published - 11 Oct 2016 |
| Event | 7th Scientific Conference on Information-Measuring Equipment and Technologies, IME and T 2016 - Tomsk, Russian Federation Duration: 25 May 2016 → 28 May 2016 |
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ASJC Scopus subject areas
- Chemistry(all)
- Engineering(all)
- Materials Science(all)
Cite this
Comparison of the Influence of "solvent/Non-Solvent" Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds. / Goreninskii, Semen; Stankevich, Ksenia Sergeevna; Bolbasov, Evgeny; Danilenko, Nadezhda; Filimonov, Victor; Tverdokhlebov, Sergei.
In: MATEC Web of Conferences, Vol. 79, 01025, 11.10.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of the Influence of "solvent/Non-Solvent" Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds
AU - Goreninskii, Semen
AU - Stankevich, Ksenia Sergeevna
AU - Bolbasov, Evgeny
AU - Danilenko, Nadezhda
AU - Filimonov, Victor
AU - Tverdokhlebov, Sergei
PY - 2016/10/11
Y1 - 2016/10/11
N2 - Electrospun biodegradable scaffolds (matrixes) made of poly(ϵ-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are three-dimensional fibrous structures that are commonly used in regenerative medicine and drug delivery systems. Modification of such structures allows manipulating with biological and immune response. Previously, our team suggested a number of surface modification strategies for thin films made of PLLA. One of the proposed strategies are based on treatment of the material with "solvent/non-solvent" mixture that allows absorbing biologically active molecules or linkers on the surface of the sample. The aim of this work was to compare the influence of "solvent/non-solvent" treatment on the structure and crystallinity of the elecrospun biodegradable PCL and PLLA scaffolds. For that purpose, original PCL and PLLA scaffolds were treated with mixture of toluene and ethanol in different proportions. Morphology of the obtained samples was studied using scanning electron microscopy. It was shown that "solvent/non-solvent" treatment doesn't lead to changes in scaffolds morphology such as gluing or cutting of the matrix fibers. By means of X-ray diffraction analysis it was shown that treatment of the samples with selected mixtures doesn't change material crystallinity. Thus, it was demonstrated that proposed composition of the "solvent/nonsolvent" mixture can be used for the modification of electrospun PCL and PLLA scaffolds.
AB - Electrospun biodegradable scaffolds (matrixes) made of poly(ϵ-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are three-dimensional fibrous structures that are commonly used in regenerative medicine and drug delivery systems. Modification of such structures allows manipulating with biological and immune response. Previously, our team suggested a number of surface modification strategies for thin films made of PLLA. One of the proposed strategies are based on treatment of the material with "solvent/non-solvent" mixture that allows absorbing biologically active molecules or linkers on the surface of the sample. The aim of this work was to compare the influence of "solvent/non-solvent" treatment on the structure and crystallinity of the elecrospun biodegradable PCL and PLLA scaffolds. For that purpose, original PCL and PLLA scaffolds were treated with mixture of toluene and ethanol in different proportions. Morphology of the obtained samples was studied using scanning electron microscopy. It was shown that "solvent/non-solvent" treatment doesn't lead to changes in scaffolds morphology such as gluing or cutting of the matrix fibers. By means of X-ray diffraction analysis it was shown that treatment of the samples with selected mixtures doesn't change material crystallinity. Thus, it was demonstrated that proposed composition of the "solvent/nonsolvent" mixture can be used for the modification of electrospun PCL and PLLA scaffolds.
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U2 - 10.1051/matecconf/20167901025
DO - 10.1051/matecconf/20167901025
M3 - Article
VL - 79
JO - MATEC Web of Conferences
JF - MATEC Web of Conferences
M1 - 01025
ER -