Abstract
LigandTracer instruments measuring high energy photons (gamma-rays), particles (electrons and positrons) and low energy photons (X-rays) are novel semi-automated devices which produce real-time radiotracer-receptor interaction data for measurement of the affinity. The affinities of two different 111In-labeled ligands were measured in three different LigandTracer devices detecting high energy gamma, Auger and internal conversion electrons, or X-rays. The obtained similar uptake/retention patterns (binding curves) show that even at low signal-to-noise ratios (data from Auger and internal conversion electrons, and X-rays), reliable binding data can be captured. This verifies that different devices could be used as alternatives for kinetic evaluation studies for radionuclides emitting different type of radiation.
Original language | English |
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Pages (from-to) | 823-828 |
Number of pages | 6 |
Journal | Journal of Radioanalytical and Nuclear Chemistry |
Volume | 304 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 May 2015 |
Externally published | Yes |
Keywords
- In
- Affinity
- Binding kinetics
- LigandTracer Grey
- LigandTracer White
- LigandTracer Yellow
ASJC Scopus subject areas
- Analytical Chemistry
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Pollution
- Spectroscopy
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis