Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

E. Bolbasov, S. Goreninskii, S. Tverdokhlebov, A. Mishanin, A. Viknianshchuk, D. Bezuidenhout, A. Golovkin

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p<0.01) and the lowest strength (p<0.01). PLC7015 scaffolds had the significantly lower average pore area (p=0.03) but the highest elastic deformation (p<0.01). Biological testing with MMSC (multipotent mesenchyme stem cells) demonstrated that after 72 hours of co-cultivation only on PCL and PLLA scaffolds cells entered to the active phase of adhesion process. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.

Original languageEnglish
Article number012012
JournalIOP Conference Series: Materials Science and Engineering
Volume350
Issue number1
DOIs
Publication statusPublished - 14 May 2018
Event2017 International Conference on Nanomaterials and Biomaterials, ICNB 2017 - Amsterdam, Netherlands
Duration: 11 Dec 201713 Dec 2017

Fingerprint

Polycaprolactone
Electrospinning
Polymer blends
Lactic acid
Scaffolds
Copolymers
Biodegradable polymers
Cell adhesion
Cell proliferation
Elastic deformation
Surface charge
Stem cells
Grafts
Topography
Wetting
Adhesion
Porosity
polycaprolactone
poly(lactic acid)
Mechanical properties

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds. / Bolbasov, E.; Goreninskii, S.; Tverdokhlebov, S.; Mishanin, A.; Viknianshchuk, A.; Bezuidenhout, D.; Golovkin, A.

In: IOP Conference Series: Materials Science and Engineering, Vol. 350, No. 1, 012012, 14.05.2018.

Research output: Contribution to journalConference article

@article{c2d2dfb487f14cd59ed1a7738a02ba97,
title = "Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds",
abstract = "Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p<0.01) and the lowest strength (p<0.01). PLC7015 scaffolds had the significantly lower average pore area (p=0.03) but the highest elastic deformation (p<0.01). Biological testing with MMSC (multipotent mesenchyme stem cells) demonstrated that after 72 hours of co-cultivation only on PCL and PLLA scaffolds cells entered to the active phase of adhesion process. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.",
author = "E. Bolbasov and S. Goreninskii and S. Tverdokhlebov and A. Mishanin and A. Viknianshchuk and D. Bezuidenhout and A. Golovkin",
year = "2018",
month = "5",
day = "14",
doi = "10.1088/1757-899X/350/1/012012",
language = "English",
volume = "350",
journal = "IOP Conference Series: Materials Science and Engineering",
issn = "1757-8981",
publisher = "IOP Publishing Ltd.",
number = "1",

}

TY - JOUR

T1 - Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

AU - Bolbasov, E.

AU - Goreninskii, S.

AU - Tverdokhlebov, S.

AU - Mishanin, A.

AU - Viknianshchuk, A.

AU - Bezuidenhout, D.

AU - Golovkin, A.

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p<0.01) and the lowest strength (p<0.01). PLC7015 scaffolds had the significantly lower average pore area (p=0.03) but the highest elastic deformation (p<0.01). Biological testing with MMSC (multipotent mesenchyme stem cells) demonstrated that after 72 hours of co-cultivation only on PCL and PLLA scaffolds cells entered to the active phase of adhesion process. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.

AB - Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p<0.01) and the lowest strength (p<0.01). PLC7015 scaffolds had the significantly lower average pore area (p=0.03) but the highest elastic deformation (p<0.01). Biological testing with MMSC (multipotent mesenchyme stem cells) demonstrated that after 72 hours of co-cultivation only on PCL and PLLA scaffolds cells entered to the active phase of adhesion process. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.

UR - http://www.scopus.com/inward/record.url?scp=85049738104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049738104&partnerID=8YFLogxK

U2 - 10.1088/1757-899X/350/1/012012

DO - 10.1088/1757-899X/350/1/012012

M3 - Conference article

AN - SCOPUS:85049738104

VL - 350

JO - IOP Conference Series: Materials Science and Engineering

JF - IOP Conference Series: Materials Science and Engineering

SN - 1757-8981

IS - 1

M1 - 012012

ER -