Comparative scintigraphic study of 99mTc ciprofloxacin pharmacokinetics after intravenous and lymphotropic administration in experimental pulmonary suppuration

Yu B. Lishmanov, Svetlana Ivanovna Sazonova, E. G. Sokolovich, V. I. Chernov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intravenously injected 99mTc ciprofloxacin is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of the antibiotic. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume139
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Pharmacokinetics
Suppuration
Intravenous Administration
Anti-Bacterial Agents
Lung
Injections
Ligaments
Liver
Pharmaceutical Preparations
Inflammation
Technetium Tc 99m ciprofloxacin

Keywords

  • Tc ciprofloxacin
  • Intravenous injections
  • Lymphotropic injections

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Comparative scintigraphic study of 99mTc ciprofloxacin pharmacokinetics after intravenous and lymphotropic administration in experimental pulmonary suppuration. / Lishmanov, Yu B.; Sazonova, Svetlana Ivanovna; Sokolovich, E. G.; Chernov, V. I.

In: Bulletin of Experimental Biology and Medicine, Vol. 139, No. 1, 01.2005, p. 94-97.

Research output: Contribution to journalArticle

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