Cognitive functions and a BDNF gene polymorphism in schizophrenia patients and healthy individuals

Anastasiia Boiko, Ekaterina Mikhalitskaya, Elena Kornetova, Svetlana Ivanova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders, and it is an important predictor of the unfavourable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) regulates a number of aspects of cell differentiation and survival; it is also required in synaptic plasticity and long-term potentiation (that determine learning and memory). In this study, we compared cognitive functions in schizophrenia cases and healthy controls. We also evaluated associations between cognitive functions and a BDNF gene polymorphism. It was a complex evaluation of 550 schizophrenia patients and 485 healthy persons. The BDNF polymorphism rs6265 was not associated with schizophrenia. Cognitive functions were evaluated in 160 schizophrenia cases and 106 healthy controls using the BACS scale. The indicators of cognitive function in schizophrenia cases were significantly worse in comparison with healthy subjects. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected with performing subtests of the BACS scale.

Original languageEnglish
Title of host publicationProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages65-67
Number of pages3
ISBN (Electronic)9781728195971
DOIs
Publication statusPublished - Jul 2020
Externally publishedYes
Event2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020 - Novosibirsk, Russian Federation
Duration: 6 Jul 202010 Jul 2020

Publication series

NameProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020

Conference

Conference2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
CountryRussian Federation
CityNovosibirsk
Period6.7.2010.7.20

Keywords

  • BDNF
  • cognitive impairment
  • gene polymorphism
  • neurocognitive deficiency
  • schizophrenia

ASJC Scopus subject areas

  • Information Systems
  • Decision Sciences (miscellaneous)
  • Cognitive Neuroscience
  • Health Informatics
  • Genetics
  • Artificial Intelligence
  • Computer Science Applications

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