TY - GEN
T1 - Cognitive functions and a BDNF gene polymorphism in schizophrenia patients and healthy individuals
AU - Boiko, Anastasiia
AU - Mikhalitskaya, Ekaterina
AU - Kornetova, Elena
AU - Ivanova, Svetlana
N1 - Funding Information:
This study was supported by the grant of RFBR #18-315-20019 “New approaches to the genetics of clinical polymorphism and neurocognitive deficits in schizophrenia”.
Publisher Copyright:
© 2020 IEEE.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders, and it is an important predictor of the unfavourable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) regulates a number of aspects of cell differentiation and survival; it is also required in synaptic plasticity and long-term potentiation (that determine learning and memory). In this study, we compared cognitive functions in schizophrenia cases and healthy controls. We also evaluated associations between cognitive functions and a BDNF gene polymorphism. It was a complex evaluation of 550 schizophrenia patients and 485 healthy persons. The BDNF polymorphism rs6265 was not associated with schizophrenia. Cognitive functions were evaluated in 160 schizophrenia cases and 106 healthy controls using the BACS scale. The indicators of cognitive function in schizophrenia cases were significantly worse in comparison with healthy subjects. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected with performing subtests of the BACS scale.
AB - In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders, and it is an important predictor of the unfavourable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) regulates a number of aspects of cell differentiation and survival; it is also required in synaptic plasticity and long-term potentiation (that determine learning and memory). In this study, we compared cognitive functions in schizophrenia cases and healthy controls. We also evaluated associations between cognitive functions and a BDNF gene polymorphism. It was a complex evaluation of 550 schizophrenia patients and 485 healthy persons. The BDNF polymorphism rs6265 was not associated with schizophrenia. Cognitive functions were evaluated in 160 schizophrenia cases and 106 healthy controls using the BACS scale. The indicators of cognitive function in schizophrenia cases were significantly worse in comparison with healthy subjects. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected with performing subtests of the BACS scale.
KW - BDNF
KW - cognitive impairment
KW - gene polymorphism
KW - neurocognitive deficiency
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85094810275&partnerID=8YFLogxK
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U2 - 10.1109/CSGB51356.2020.9214770
DO - 10.1109/CSGB51356.2020.9214770
M3 - Conference contribution
AN - SCOPUS:85094810275
T3 - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
SP - 65
EP - 67
BT - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
Y2 - 6 July 2020 through 10 July 2020
ER -