closo-dodecaborarte (2-) anion as a potential prosthetic group for attachment of astatine to proteins. Aspects of the labelling chemistry with Chloramine-T

Anna Orlova, Ondrej Lebeda, Vladimir Tolmachev, Stefan Sjöberg, Jörgen Carlsson, Hans Lundqvist

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Closo-dodecaborate (2-) was proposed as a prosthetic group for direct labelling of proteins with 211At for radionuclide therapy. Astatination of closo-dodecaborate (2-) anion using Chloramine-T was studied, and the influence of pH, reaction time, amount of substrate and oxidant was determined. A maximum labelling yield of 55-75% was found in the pH range 7-8. A spontaneous astatination of closo-dodecaborate (2-) in the absence of Chloramine-T was also found, presumably due to generation of oxidising products from water radiolysis, Our results of indicate that derivatives of closo-dodecaborate (2-) anion may be used as prosthetic groups for direct labelling of proteins.

Original languageEnglish
Pages (from-to)251-260
Number of pages10
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume43
Issue number3
DOIs
Publication statusPublished - 15 Mar 2000
Externally publishedYes

Keywords

  • At
  • Astatination
  • Chloramine-T
  • closo-dodecaborate (2-) anion

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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