Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy

Sh D. Akhmedov, V. E. Babokin, V. V. Ryabov, T. E. Suslova, V. I. Chernov, S. I. Sazonova, Yu V. Rogovskaya, Yu G. Korkin, A. P. Motreva, V. M. Shipulin, R. S. Karpov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Between March 2003 and February 2005 cell therapy with mononuclear bone marrow cells (MBMC) was used in 38 and 4 patients with ischemic heart disease and dilated cardiomyopathy, respectively. Intracardiac administration of MBMC (87±12 millions) was carried out during coronary artery bypass surgery and/or left ventricular aneurism resection (n=25) or in cardiac catheterization laboratory (n=17). For verification of cells fixation they were labeled with "Ceretec" 99mTc-HMPAO. Accumulation of labeled cells after 24 hours was 1.6±0.001%. After 6 months parameters of intracardiac hemodynamics and transitory myocardial perfusion defects improved significantly in all patients with ischemic heart disease.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalKardiologiya
Volume46
Issue number7
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • Cell therapy
  • Cellular cardiomyoplasty
  • Heart failure, treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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