Clinical and electrophysiological parameters of alcohol dependence and its comorbidity with affective disorders

S. A. Galkin, O. V. Roshchina, N. I. Kisel, S. A. Ivanova, N. A. Bokhan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To identify characteristics of and possible differences in clinical and electroencephalographic parameters in patients with alcohol dependence with-and without comorbid affective disorders. Materials and methods. Ninety-five patients, including 74 with an established diagnosis of alcohol dependence and 21 with alcohol dependence and affective disorders, were examined. Duration of alcohol dependence and affective disorder (years), number of hospitalizations and suicidal attempts were analyzed as anamnestic data. Hamilton’s anxiety and depression scale (HDRS), the Alcohol Use Disorders Identification Test (AUDIT), the General clinical impression scale (CGI-s) were used as psychometric tools. The study of bioelectric activity of the brain was carried out using a 16-channel encephalograph. The background electroencephalogram was recorded, the values of absolute spectral power and coherence of theta, alpha and beta rhythms were analyzed. Results and conclusion. Patients with comorbidity of alcohol dependence and affective disorders have a significantly higher risk of suicidal behavior, a greater frequency of hospitalizations, higher levels of anxiety compared with patients without affective dis-orders. Electrophysiological data have shown that patients with comorbidity of alcohol dependence and affective disorders have higher values of spectral power of alpha-rhythm in all parts of the cerebral cortex (except for temporal lobes) and beta-rhythm in the occipital cortex, as well as an increase in interhemispheric coherence in all frequency ranges.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalZhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
Volume120
Issue number10
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Affective disorders
  • Alcohol dependence
  • Clinical characteristics
  • Comorbidity
  • Electroencephalography

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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