Click chemistry on diterpenes: Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations

Sergey F. Vasilevsky, Denis S. Baranov, Anastasia I. Govdi, Irina V. Sorokina, Tatyana G. Tolstikova, Genrikh A. Tolstikov, Igor V. Alabugin

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.

Original language	English
Pages (from-to)	145-157
Number of pages	13
Journal	Arkivoc
Volume	2014
Issue number	5
DOIs	https://doi.org/10.3998/ark.5550190.p008.471
Publication status	Published - 19 Jul 2014
Externally published	Yes

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Keywords

1,2,3-triazole
Acetylenes
Antiinflammatory activity
Click Chemistry
Diterpenoids
Levopimaric acid

ASJC Scopus subject areas

Organic Chemistry

Cite this

Vasilevsky, S. F., Baranov, D. S., Govdi, A. I., Sorokina, I. V., Tolstikova, T. G., Tolstikov, G. A., & Alabugin, I. V. (2014). Click chemistry on diterpenes: Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. Arkivoc, 2014(5), 145-157. https://doi.org/10.3998/ark.5550190.p008.471

Click chemistry on diterpenes : Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. / Vasilevsky, Sergey F.; Baranov, Denis S.; Govdi, Anastasia I.; Sorokina, Irina V.; Tolstikova, Tatyana G.; Tolstikov, Genrikh A.; Alabugin, Igor V.

In: Arkivoc, Vol. 2014, No. 5, 19.07.2014, p. 145-157.

Research output: Contribution to journal › Article

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10.3998/ark.5550190.p008.471