Abstract
Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.
| Original language | English |
|---|---|
| Pages (from-to) | 145-157 |
| Number of pages | 13 |
| Journal | Arkivoc |
| Volume | 2014 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 19 Jul 2014 |
| Externally published | Yes |
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Keywords
- 1,2,3-triazole
- Acetylenes
- Antiinflammatory activity
- Click Chemistry
- Diterpenoids
- Levopimaric acid
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Click chemistry on diterpenes : Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. / Vasilevsky, Sergey F.; Baranov, Denis S.; Govdi, Anastasia I.; Sorokina, Irina V.; Tolstikova, Tatyana G.; Tolstikov, Genrikh A.; Alabugin, Igor V.
In: Arkivoc, Vol. 2014, No. 5, 19.07.2014, p. 145-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Click chemistry on diterpenes
T2 - Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations
AU - Vasilevsky, Sergey F.
AU - Baranov, Denis S.
AU - Govdi, Anastasia I.
AU - Sorokina, Irina V.
AU - Tolstikova, Tatyana G.
AU - Tolstikov, Genrikh A.
AU - Alabugin, Igor V.
PY - 2014/7/19
Y1 - 2014/7/19
N2 - Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.
AB - Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.
KW - 1,2,3-triazole
KW - Acetylenes
KW - Antiinflammatory activity
KW - Click Chemistry
KW - Diterpenoids
KW - Levopimaric acid
UR - http://www.scopus.com/inward/record.url?scp=84905592935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905592935&partnerID=8YFLogxK
U2 - 10.3998/ark.5550190.p008.471
DO - 10.3998/ark.5550190.p008.471
M3 - Article
VL - 2014
SP - 145
EP - 157
JO - Arkivoc
JF - Arkivoc
SN - 1424-6376
IS - 5
ER -