Click chemistry on diterpenes

Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations

Sergey F. Vasilevsky, Denis S. Baranov, Anastasia I. Govdi, Irina V. Sorokina, Tatyana G. Tolstikova, Genrikh A. Tolstikov, Igor V. Alabugin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.

Original languageEnglish
Pages (from-to)145-157
Number of pages13
JournalArkivoc
Volume2014
Issue number5
DOIs
Publication statusPublished - 19 Jul 2014
Externally publishedYes

Fingerprint

Diterpenes
Anti-Inflammatory Agents
Derivatives
Acids
Amides
Indomethacin
Histamine
Esters
Substitution reactions

Keywords

  • 1,2,3-triazole
  • Acetylenes
  • Antiinflammatory activity
  • Click Chemistry
  • Diterpenoids
  • Levopimaric acid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Click chemistry on diterpenes : Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. / Vasilevsky, Sergey F.; Baranov, Denis S.; Govdi, Anastasia I.; Sorokina, Irina V.; Tolstikova, Tatyana G.; Tolstikov, Genrikh A.; Alabugin, Igor V.

In: Arkivoc, Vol. 2014, No. 5, 19.07.2014, p. 145-157.

Research output: Contribution to journalArticle

Vasilevsky, Sergey F. ; Baranov, Denis S. ; Govdi, Anastasia I. ; Sorokina, Irina V. ; Tolstikova, Tatyana G. ; Tolstikov, Genrikh A. ; Alabugin, Igor V. / Click chemistry on diterpenes : Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. In: Arkivoc. 2014 ; Vol. 2014, No. 5. pp. 145-157.
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