Abstract
Anti-inflammatory activity of amides of levopimaric acid (LpA) with acetylenic moiety and its esters with 4-R-triazolic substitutions was investigated using histamine-induced mice paw edema model. The synthesized LpA derivatives possess anti-inflammatory activity comparable to the activity of indomethacin.
| Original language | English |
|---|---|
| Pages (from-to) | 145-157 |
| Number of pages | 13 |
| Journal | Arkivoc |
| Volume | 2014 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 19 Jul 2014 |
| Externally published | Yes |
Keywords
- 1,2,3-triazole
- Acetylenes
- Antiinflammatory activity
- Click Chemistry
- Diterpenoids
- Levopimaric acid
ASJC Scopus subject areas
- Organic Chemistry
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Vasilevsky, S. F., Baranov, D. S., Govdi, A. I., Sorokina, I. V., Tolstikova, T. G., Tolstikov, G. A., & Alabugin, I. V. (2014). Click chemistry on diterpenes: Anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations. Arkivoc, 2014(5), 145-157. https://doi.org/10.3998/ark.5550190.p008.471