Click and pick: Identification of sialoside analogues for siglec-based cell targeting

Cory D. Rillahan, Erik Schwartz, Ryan McBride, Valery V. Fokin, James C. Paulson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Click 'n' chips: Azide and alkyne-bearing sialic acids (purple diamond; see picture) were subjected to high-throughput click chemistry to generate a library of sialic acid analogues. Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.

Original languageEnglish
Pages (from-to)11014-11018
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number44
DOIs
Publication statusPublished - 29 Oct 2012
Externally publishedYes

Keywords

  • carbohydrates
  • immunology
  • liposomes
  • receptors
  • sialic acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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