Chemical modification of plant alkaloids. 4. Reaction of cotarnine with bifunctional NH- and CH-acids

K. A. Krasnov, V. G. Kartsev, S. F. Vasilevskii

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1-Substituted 1,2,3,4-tetrahydroisoquinoline systems were prepared by reaction of cotarnine with the NH-and CH-acids methyl- and acyl derivatives of pyrazole and 1,3-dicarbonyl reagents. Depending on the structure and reaction conditions, bifunctional pyrazole nucleophiles can give substitution products at the N atom, methyl, or acyl group; 1,3-diketones, at the terminal methyl. Rearrangements occurring during the reaction of cotarnine with bifunctional substrates were studied.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalChemistry of Natural Compounds
Volume41
Issue number4
DOIs
Publication statusPublished - 1 Jul 2005
Externally publishedYes

Keywords

  • 1,3-Dicarbonyls
  • Cotarnine
  • Pyrazoles
  • Rearrangement

ASJC Scopus subject areas

  • Plant Science

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