Chemical modification of plant alkaloids. 4. Reaction of cotarnine with bifunctional NH- and CH-acids

K. A. Krasnov, V. G. Kartsev, S. F. Vasilevskii

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1-Substituted 1,2,3,4-tetrahydroisoquinoline systems were prepared by reaction of cotarnine with the NH-and CH-acids methyl- and acyl derivatives of pyrazole and 1,3-dicarbonyl reagents. Depending on the structure and reaction conditions, bifunctional pyrazole nucleophiles can give substitution products at the N atom, methyl, or acyl group; 1,3-diketones, at the terminal methyl. Rearrangements occurring during the reaction of cotarnine with bifunctional substrates were studied.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalChemistry of Natural Compounds
Volume41
Issue number4
DOIs
Publication statusPublished - 1 Jul 2005
Externally publishedYes

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pyrazoles
alkaloids
tetrahydroisoquinolines
acids

Keywords

  • 1,3-Dicarbonyls
  • Cotarnine
  • Pyrazoles
  • Rearrangement

ASJC Scopus subject areas

  • Plant Science

Cite this

Chemical modification of plant alkaloids. 4. Reaction of cotarnine with bifunctional NH- and CH-acids. / Krasnov, K. A.; Kartsev, V. G.; Vasilevskii, S. F.

In: Chemistry of Natural Compounds, Vol. 41, No. 4, 01.07.2005, p. 446-450.

Research output: Contribution to journalArticle

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