Chemical composition and biological activity of a fraction of meadowsweet extract

Abstract

Studies of the chemical composition of a butanol fraction of an extract from the above-ground part of the meadowsweet in 70% ethanol yielded five substances which were flavonoids (quercetin, isoquercetin, quercetin 4?-glucoside, rutin) and phenolcarboxylic acids (gallic acid). The fraction was found to have nootropic actions, with antiamnestic, antihypoxic, antioxidant, and adaptogenic activities. Studies of the antioxidant properties of the individual compounds showed that isoquercetin, quercetin 4?-glucoside, and rutin were more active than dihydroquercetin and ascorbic acid.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	Pharmaceutical Chemistry Journal
Volume	43
Issue number	4
DOIs	https://doi.org/10.1007/s11094-009-0275-2
Publication status	Published - Apr 2009

Keywords

Antioxidant activity
Meadowsweet
Nootropic activity
Phenol compounds

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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10.1007/s11094-009-0275-2

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title = "Chemical composition and biological activity of a fraction of meadowsweet extract",

abstract = "Studies of the chemical composition of a butanol fraction of an extract from the above-ground part of the meadowsweet in 70% ethanol yielded five substances which were flavonoids (quercetin, isoquercetin, quercetin 4?-glucoside, rutin) and phenolcarboxylic acids (gallic acid). The fraction was found to have nootropic actions, with antiamnestic, antihypoxic, antioxidant, and adaptogenic activities. Studies of the antioxidant properties of the individual compounds showed that isoquercetin, quercetin 4?-glucoside, and rutin were more active than dihydroquercetin and ascorbic acid.",

keywords = "Antioxidant activity, Meadowsweet, Nootropic activity, Phenol compounds",

author = "Shilova, {I. V.} and Semenov, {A. A.} and Suslov, {N. I.} and Korotkova, {E. I.} and Vtorushina, {Anna Nikolaevna} and Belyakova, {V. V.}",

year = "2009",

month = apr,

doi = "10.1007/s11094-009-0275-2",

language = "English",

volume = "43",

pages = "185--190",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

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TY - JOUR

T1 - Chemical composition and biological activity of a fraction of meadowsweet extract

AU - Shilova, I. V.

AU - Semenov, A. A.

AU - Suslov, N. I.

AU - Korotkova, E. I.

AU - Vtorushina, Anna Nikolaevna

AU - Belyakova, V. V.

PY - 2009/4

Y1 - 2009/4

N2 - Studies of the chemical composition of a butanol fraction of an extract from the above-ground part of the meadowsweet in 70% ethanol yielded five substances which were flavonoids (quercetin, isoquercetin, quercetin 4?-glucoside, rutin) and phenolcarboxylic acids (gallic acid). The fraction was found to have nootropic actions, with antiamnestic, antihypoxic, antioxidant, and adaptogenic activities. Studies of the antioxidant properties of the individual compounds showed that isoquercetin, quercetin 4?-glucoside, and rutin were more active than dihydroquercetin and ascorbic acid.

AB - Studies of the chemical composition of a butanol fraction of an extract from the above-ground part of the meadowsweet in 70% ethanol yielded five substances which were flavonoids (quercetin, isoquercetin, quercetin 4?-glucoside, rutin) and phenolcarboxylic acids (gallic acid). The fraction was found to have nootropic actions, with antiamnestic, antihypoxic, antioxidant, and adaptogenic activities. Studies of the antioxidant properties of the individual compounds showed that isoquercetin, quercetin 4?-glucoside, and rutin were more active than dihydroquercetin and ascorbic acid.

KW - Antioxidant activity

KW - Meadowsweet

KW - Nootropic activity

KW - Phenol compounds

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DO - 10.1007/s11094-009-0275-2

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JO - Pharmaceutical Chemistry Journal

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