Chemical composition and biological activity of a fraction of meadowsweet extract

I. V. Shilova, A. A. Semenov, N. I. Suslov, E. I. Korotkova, Anna Nikolaevna Vtorushina, V. V. Belyakova

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3 Citations (Scopus)

Abstract

Studies of the chemical composition of a butanol fraction of an extract from the above-ground part of the meadowsweet in 70% ethanol yielded five substances which were flavonoids (quercetin, isoquercetin, quercetin 4?-glucoside, rutin) and phenolcarboxylic acids (gallic acid). The fraction was found to have nootropic actions, with antiamnestic, antihypoxic, antioxidant, and adaptogenic activities. Studies of the antioxidant properties of the individual compounds showed that isoquercetin, quercetin 4?-glucoside, and rutin were more active than dihydroquercetin and ascorbic acid.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalPharmaceutical Chemistry Journal
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2009

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Keywords

  • Antioxidant activity
  • Meadowsweet
  • Nootropic activity
  • Phenol compounds

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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