Characterization of a Novel Dioxomolybdenum Complex by Cyclic Voltammetry

Esther Theresa Knittl, D. A. Rusakov, E. I. Korotkova, E. V. Dorozhko, Olesya Alexandrovna Voronova, E. V. Plotnikov, Isil Topaloglu-Sozuer, Wolfgang Linert

Research output: Contribution to journalArticle

Abstract

Metalloenzymes that carry a pterin-based molybdenum cofactor in their center catalyze numerous reactions in the human body and play a crucial role in its metabolism. Specifically, these enzymes promote redox reactions and oxygen transport in the body. Their absence may cause many problems leading to disability or even death in early childhood. Therefore, model compounds need to be synthesized and analyzed to investigate the reactivity, redox potential, and geometry of these cofactors. This study focused on electrode processes and determined the redox potentials of the new bis-(4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione)-dioxomolybdenum complex by cyclic voltammetry. The 4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione ligand underwent irreversible oxidation and reduction at thiol and thione functional groups. The new dioxomolybdenum complex showed a quasi-reversible two-stage electrode process.

Original languageEnglish
Pages (from-to)2369-2379
Number of pages11
JournalAnalytical Letters
Volume48
Issue number15
DOIs
Publication statusPublished - 13 Oct 2015

Fingerprint

Cyclic voltammetry
Oxidation-Reduction
Pterins
Thiones
Electrodes
Redox reactions
Sulfhydryl Compounds
Metabolism
Functional groups
Molybdenum
Enzymes
Ligands
Oxygen
Oxidation
Geometry
Human Body
1,2-dithiol-3-thione
molybdenum cofactor

Keywords

  • Cyclic voltammetry
  • Dioxomolybdenum complex
  • Glassy carbon electrode
  • Redox properties

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry
  • Spectroscopy

Cite this

Characterization of a Novel Dioxomolybdenum Complex by Cyclic Voltammetry. / Knittl, Esther Theresa; Rusakov, D. A.; Korotkova, E. I.; Dorozhko, E. V.; Voronova, Olesya Alexandrovna; Plotnikov, E. V.; Topaloglu-Sozuer, Isil; Linert, Wolfgang.

In: Analytical Letters, Vol. 48, No. 15, 13.10.2015, p. 2369-2379.

Research output: Contribution to journalArticle

Knittl, Esther Theresa ; Rusakov, D. A. ; Korotkova, E. I. ; Dorozhko, E. V. ; Voronova, Olesya Alexandrovna ; Plotnikov, E. V. ; Topaloglu-Sozuer, Isil ; Linert, Wolfgang. / Characterization of a Novel Dioxomolybdenum Complex by Cyclic Voltammetry. In: Analytical Letters. 2015 ; Vol. 48, No. 15. pp. 2369-2379.
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