Characterization and in vitro and in vivo assessment of a novel cellulose acetate-coated Mg-based alloy for orthopedic applications

Patricia Neacsu, Adela Ioana Staras, Stefan Ioan Voicu, Iuliana Ionascu, Teodoru Soare, Seralp Uzun, Vasile Danut Cojocaru, Andreea Madalina Pandele, Sorin Mihai Croitoru, Florin Miculescu, Cosmin Mihai Cotrut, Ioan Dan, Anisoara Cimpean

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19 Citations (Scopus)

Abstract

Despite their good biocompatibility and adequate mechanical behavior, the main limitation of Mg alloys might be their high degradation rates in a physiological environment. In this study, a novel Mg-based alloy exhibiting an elastic modulus E = 42 GPa, Mg-1Ca-0.2Mn-0.6Zr, was synthesized and thermo-mechanically processed. In order to improve its performance as a temporary bone implant, a coating based on cellulose acetate (CA) was realized by using the dipping method. The formation of the polymer coating was demonstrated by FT-IR, XPS, SEM and corrosion behavior comparative analyses of both uncoated and CA-coated alloys. The potentiodynamic polarization test revealed that the CA coating significantly improved the corrosion resistance of the Mg alloy. Using a series of in vitro and in vivo experiments, the biocompatibility of both groups of biomaterials was assessed. In vitro experiments demonstrated that the media containing their extracts showed good cytocompatibility on MC3T3-E1 pre-osteoblasts in terms of cell adhesion and spreading, viability, proliferation and osteogenic differentiation. In vivo studies conducted in rats revealed that the intramedullary coated implant for fixation of femur fracture was more efficient in inducing bone regeneration than the uncoated one. In this manner, the present study suggests that the CA-coated Mg-based alloy holds promise for orthopedic aplications.

Original languageEnglish
Article number686
JournalMaterials
Volume10
Issue number7
DOIs
Publication statusPublished - 22 Jun 2017

Keywords

  • Cellulose acetate coating
  • Corrosion
  • In vivo behavior
  • Magnesium alloy
  • Osteoblast

ASJC Scopus subject areas

  • Materials Science(all)

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    Neacsu, P., Staras, A. I., Voicu, S. I., Ionascu, I., Soare, T., Uzun, S., Cojocaru, V. D., Pandele, A. M., Croitoru, S. M., Miculescu, F., Cotrut, C. M., Dan, I., & Cimpean, A. (2017). Characterization and in vitro and in vivo assessment of a novel cellulose acetate-coated Mg-based alloy for orthopedic applications. Materials, 10(7), [686]. https://doi.org/10.3390/ma10070686