Characterization and evaluation of silica particles coated by PVP and albumin for effective bilirubin removal

Alexander S. Timin, Alexey V. Solomonov, Irek I. Musabirov, Semen N. Sergeev, Sergey P. Ivanov, Evgeniy V. Rumyantsev

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Polyvinylpyrrolidone (PVP) modified silica coated with albumin as host matrices for bilirubin removal were synthesized through sol–gel method. Such materials were characterized by scanning electron microscopy, nitrogen adsorption, Fourier transform spectroscopy and elemental analysis. It was shown that PVP grafted onto silica provides strong and high immobilization of BSA in comparison with pure silica. These modified silicas with different content of BSA were used to study bilirubin adsorption from the bilirubin–phosphate solutions (pH 7.4). The effect of time, ionic strength and concentration on the bilirubin adsorption were investigated as well. The results demonstrate that the adsorption capacity of tested samples increases after surface modification. The maximum adsorption capacity for bilirubin was 2.82 mg/g.

Original languageEnglish
Pages (from-to)187-198
Number of pages12
JournalJournal of Sol-Gel Science and Technology
Volume74
Issue number1
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Adsorption
  • Albumin
  • Bilirubin
  • Functionalization
  • Silicas
  • Sol–gel

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Biomaterials
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

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