Changes in cerebral blood flow and cognitive function in patients undergoing coronary bypass surgery with cardiopulmonary bypass

Nataliya Yurievna Efimova, V. Chernov, I. Efimova, Sh Akhmedov, Yu Lishmanov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: to study effect of coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) on regional cerebral blood flow and cognitive function in patients with ischemic heart disease (I HD). Material and methods. We included into this study 22 patients with IHD subjected to CABG surgery with CPB. All patients underwent brain SPECT scanning and comprehensive neuropsychological testing 1 day before, 10-14 days and 6 months after surgery. Results. Overall CABG with CPB was followed by reduction of regional cerebral blood flow relative to baseline in frontal and parietal cortex (p5%) of cerebral perfusion in early postoperative period was observed in 15 patients (68%) while seven patients (32%) had no significant changes of regional cerebral blood flow. Changes of cerebral perfusion correlated with dynamics of cognitive status. Mean measures of immediate verbal memory, delayed memory, and learning decreased after surgery by 25.6 (p=0.002), 43.3 (p=0.000003), and 23.1% (p=0.00000), respectively. Moreover after CABG with CPB patients demonstrated slowing of psychomotor speed by 13.6% (p=0.03). Conclusion. CABG with CPB was associated with reduction of cerebral perfusion leading to cognitive dysfunction. Immediate and delayed verbal and visual memory, learning and psychomotor speed were most sensitive to the negative effects of surgery.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalKardiologiya
Volume55
Issue number6
Publication statusPublished - 2015

Fingerprint

Cerebrovascular Circulation
Cardiopulmonary Bypass
Cognition
Coronary Artery Bypass
Transplants
Regional Blood Flow
Perfusion
Learning
Repression (Psychology)
Parietal Lobe
Frontal Lobe
Single-Photon Emission-Computed Tomography
Short-Term Memory
Postoperative Period
Myocardial Ischemia
Brain

Keywords

  • Brain perfusion
  • Cardiopulmonary bypass
  • Coronary artery bypass grafting
  • Neuropsychological disorders
  • Single photon emission computer tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Changes in cerebral blood flow and cognitive function in patients undergoing coronary bypass surgery with cardiopulmonary bypass. / Efimova, Nataliya Yurievna; Chernov, V.; Efimova, I.; Akhmedov, Sh; Lishmanov, Yu.

In: Kardiologiya, Vol. 55, No. 6, 2015, p. 40-46.

Research output: Contribution to journalArticle

Efimova, Nataliya Yurievna ; Chernov, V. ; Efimova, I. ; Akhmedov, Sh ; Lishmanov, Yu. / Changes in cerebral blood flow and cognitive function in patients undergoing coronary bypass surgery with cardiopulmonary bypass. In: Kardiologiya. 2015 ; Vol. 55, No. 6. pp. 40-46.
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