Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model

Shuning Huang, Jeong Kon Kim, Dmitriy N. Atochin, Christian T. Farrar, Paul L. Huang, Ji Yeon Suh, Seon Joo Kwon, Woo Hyun Shim, Hyungjoon Cho, Gyunggoo Cho, Young Ro Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Insufficient vascular reserve after an ischemic stroke may induce biochemical cascades that subsequently deteriorate the blood-brain barrier (BBB) function. However, the direct relationship between poor cerebral blood volume (CBV) restoration and BBB disruption has not been examined in acute stroke. To quantify BBB integrity at acute stages of transient stroke, in particular for cases in which extravasation of the standard contrast agent (Gd-DTPA) is not observed, we adopted the water exchange index (WEI), a novel magnetic resonance image-derived parameter to estimate the water permeability across the BBB. The apparent diffusion coefficient (ADC) and R 2 relaxation rate constant were also measured for outlining the tissue abnormality, while fractional CBV and WEI were quantified for assessing vascular alterations. The significantly decreased ADC and R 2 in the ischemic cortices did not correlate with the changes in CBV or WEI. In contrast, a strong negative correlation between the ipsilesional WEI and CBV was found, in which stroke mice were clustered into two groups: (1) high WEI and low CBV and (2) normal WEI and CBV. The low CBV observed for mice with a disrupted BBB, characterized by a high WEI, indicates the importance of CBV restoration for maintaining BBB stability in acute stroke.

Original languageEnglish
Pages (from-to)898-905
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Cerebral blood volume
  • MRI
  • Stroke
  • Water exchange

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

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  • Cite this

    Huang, S., Kim, J. K., Atochin, D. N., Farrar, C. T., Huang, P. L., Suh, J. Y., Kwon, S. J., Shim, W. H., Cho, H., Cho, G., & Kim, Y. R. (2013). Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model. Journal of Cerebral Blood Flow and Metabolism, 33(6), 898-905. https://doi.org/10.1038/jcbfm.2013.27