Cerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome: Effect of Antihypertensive Therapy

Abstract

The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.

Original language	English
Pages (from-to)	900-906
Number of pages	7
Journal	Journal of Clinical Hypertension
Volume	16
Issue number	12
DOIs	https://doi.org/10.1111/jch.12435
Publication status	Published - 1 Dec 2014

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1111/jch.12435

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title = "Cerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome: Effect of Antihypertensive Therapy",

abstract = "The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.",

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