Abstract
The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.
| Original language | English |
|---|---|
| Pages (from-to) | 900-906 |
| Number of pages | 7 |
| Journal | Journal of Clinical Hypertension |
| Volume | 16 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2014 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Cerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome : Effect of Antihypertensive Therapy. / Efimova, Irina; Efimova, Nataliya Yurievna; Lishmanov, Yuri.
In: Journal of Clinical Hypertension, Vol. 16, No. 12, 01.12.2014, p. 900-906.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome
T2 - Effect of Antihypertensive Therapy
AU - Efimova, Irina
AU - Efimova, Nataliya Yurievna
AU - Lishmanov, Yuri
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.
AB - The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.
UR - http://www.scopus.com/inward/record.url?scp=84919627192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919627192&partnerID=8YFLogxK
U2 - 10.1111/jch.12435
DO - 10.1111/jch.12435
M3 - Article
VL - 16
SP - 900
EP - 906
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
SN - 1524-6175
IS - 12
ER -