Central κ<sub>1</sub>-opiate receptors and mechanisms of arrhythmogenesis

Abstract

Agonists of κ₁-opiate receptors injected in brain ventricle potentiate arrhythmogenic effect of adrenaline. Antagonist of κ₁-opiate receptors norbinaltorphimine or ganglioblocker hexamethonium completely abolish proarrythmic effects of κ₁-agonists. Norbinaltorphimine possesses intrinsic antiarrhythmic activity.

Original language	English
Pages (from-to)	571-573
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	123
Issue number	6
DOIs	https://doi.org/10.1007/BF02458080
Publication status	Published - 1 Jan 1997

Keywords

Arrhythmias
κ-opiate receptors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF02458080

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title = "Central κ1-opiate receptors and mechanisms of arrhythmogenesis",

abstract = "Agonists of κ1-opiate receptors injected in brain ventricle potentiate arrhythmogenic effect of adrenaline. Antagonist of κ1-opiate receptors norbinaltorphimine or ganglioblocker hexamethonium completely abolish proarrythmic effects of κ1-agonists. Norbinaltorphimine possesses intrinsic antiarrhythmic activity.",

keywords = "Arrhythmias, κ-opiate receptors",

author = "Ugdyzhekova, {D. S.} and Maslov, {L. N.} and Lishmanov, {Yu B.}",

year = "1997",

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AU - Maslov, L. N.

AU - Lishmanov, Yu B.

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AB - Agonists of κ1-opiate receptors injected in brain ventricle potentiate arrhythmogenic effect of adrenaline. Antagonist of κ1-opiate receptors norbinaltorphimine or ganglioblocker hexamethonium completely abolish proarrythmic effects of κ1-agonists. Norbinaltorphimine possesses intrinsic antiarrhythmic activity.

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