Central κ₁-opiate receptors and mechanisms of arrhythmogenesis

D. S. Ugdyzhekova, L. N. Maslov, Yu B. Lishmanov

Research Nuclear Reactor Center

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Abstract

Agonists of κ₁-opiate receptors injected in brain ventricle potentiate arrhythmogenic effect of adrenaline. Antagonist of κ₁-opiate receptors norbinaltorphimine or ganglioblocker hexamethonium completely abolish proarrythmic effects of κ₁-agonists. Norbinaltorphimine possesses intrinsic antiarrhythmic activity.

Original language	English
Pages (from-to)	571-573
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	123
Issue number	6
DOIs	https://doi.org/10.1007/BF02458080
Publication status	Published - 1 Jan 1997

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Keywords

Arrhythmias
κ-opiate receptors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ugdyzhekova, D. S., Maslov, L. N., & Lishmanov, Y. B. (1997). Central κ₁-opiate receptors and mechanisms of arrhythmogenesis. Bulletin of Experimental Biology and Medicine, 123(6), 571-573. https://doi.org/10.1007/BF02458080

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Access to Document

10.1007/BF02458080