Abstract
Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.
Original language | English |
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Pages (from-to) | 50-52 |
Number of pages | 3 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 127 |
Issue number | 1 |
Publication status | Published - Jan 1999 |
Keywords
- κ-opiate receptors
- Arrhythmias
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)