Central κ1-opiate receptors and mechanisms of arrhythmias

D. S. Ugdyzhekova, L. N. Maslov, Yu B. Lishmanov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume127
Issue number1
Publication statusPublished - Jan 1999

Keywords

  • κ-opiate receptors
  • Arrhythmias

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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