Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.
|Number of pages||3|
|Journal||Bulletin of Experimental Biology and Medicine|
|Publication status||Published - Jan 1999|
- κ-opiate receptors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)