Central κ<sub>1</sub>-opiate receptors and mechanisms of arrhythmias

Abstract

Intracerebroventricular infusion of κ₁-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ₁-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ₁-receptors play an important role in the regulation of arrhythmias.

Original language	English
Pages (from-to)	50-52
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	127
Issue number	1
Publication status	Published - Jan 1999

Keywords

κ-opiate receptors
Arrhythmias

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Central κ1-opiate receptors and mechanisms of arrhythmias",

abstract = "Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.",

keywords = "κ-opiate receptors, Arrhythmias",

author = "Ugdyzhekova, {D. S.} and Maslov, {L. N.} and Lishmanov, {Yu B.}",

year = "1999",

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language = "English",

volume = "127",

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journal = "Bulletin of Experimental Biology and Medicine",

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AU - Ugdyzhekova, D. S.

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

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Y1 - 1999/1

N2 - Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.

AB - Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.

KW - κ-opiate receptors

KW - Arrhythmias

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