Central κ<sub>1</sub>-opiate receptors and mechanisms of arrhythmias

Abstract

Intracerebroventricular infusion of κ₁-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ₁-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ₁-receptors play an important role in the regulation of arrhythmias.

Original language	English
Pages (from-to)	50-52
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	127
Issue number	1
Publication status	Published - Jan 1999

Keywords

κ-opiate receptors
Arrhythmias

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Ugdyzhekova, D. S., Maslov, L. N., & Lishmanov, Y. B. (1999). Central κ₁-opiate receptors and mechanisms of arrhythmias. Bulletin of Experimental Biology and Medicine, 127(1), 50-52.

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AB - Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.

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