Abstract
Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.
| Original language | English |
|---|---|
| Pages (from-to) | 50-52 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 127 |
| Issue number | 1 |
| Publication status | Published - Jan 1999 |
Fingerprint
Keywords
- κ-opiate receptors
- Arrhythmias
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Central κ1-opiate receptors and mechanisms of arrhythmias. / Ugdyzhekova, D. S.; Maslov, L. N.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 127, No. 1, 01.1999, p. 50-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central κ1-opiate receptors and mechanisms of arrhythmias
AU - Ugdyzhekova, D. S.
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
PY - 1999/1
Y1 - 1999/1
N2 - Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.
AB - Intracerebroventricular infusion of κ1-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ1-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ1-receptors play an important role in the regulation of arrhythmias.
KW - κ-opiate receptors
KW - Arrhythmias
UR - http://www.scopus.com/inward/record.url?scp=0005189673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0005189673&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0005189673
VL - 127
SP - 50
EP - 52
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -