Central κ₁-opiate receptors and mechanisms of arrhythmias

D. S. Ugdyzhekova, L. N. Maslov, Yu B. Lishmanov

Research Nuclear Reactor Center

Research output: Contribution to journal › Article

Abstract

Intracerebroventricular infusion of κ₁-opiate receptor agonists potentiated cardiac arrhythmias elicited by epinephrine. This effect was completely reversed by the κ₁-receptor antagonist norbintaltorphymine and the ganglioblocker hexamethonium. Norbintaltorphymine also exhibited an antiarrhythmic activity. It is suggested that endogenous ligands of κ₁-receptors play an important role in the regulation of arrhythmias.

Original language	English
Pages (from-to)	50-52
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	127
Issue number	1
Publication status	Published - Jan 1999

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Hexamethonium

Opioid Receptors

Epinephrine

Cardiac Arrhythmias

Intraventricular Infusions

Ligands

Keywords

κ-opiate receptors
Arrhythmias

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ugdyzhekova, D. S., Maslov, L. N., & Lishmanov, Y. B. (1999). Central κ₁-opiate receptors and mechanisms of arrhythmias. Bulletin of Experimental Biology and Medicine, 127(1), 50-52.

Central κ₁-opiate receptors and mechanisms of arrhythmias. / Ugdyzhekova, D. S.; Maslov, L. N.; Lishmanov, Yu B.

In: Bulletin of Experimental Biology and Medicine, Vol. 127, No. 1, 01.1999, p. 50-52.

Research output: Contribution to journal › Article

Ugdyzhekova, DS, Maslov, LN & Lishmanov, YB 1999, 'Central κ₁-opiate receptors and mechanisms of arrhythmias', Bulletin of Experimental Biology and Medicine, vol. 127, no. 1, pp. 50-52.

Ugdyzhekova DS, Maslov LN, Lishmanov YB. Central κ₁-opiate receptors and mechanisms of arrhythmias. Bulletin of Experimental Biology and Medicine. 1999 Jan;127(1):50-52.

Ugdyzhekova, D. S. ; Maslov, L. N. ; Lishmanov, Yu B. / Central κ₁-opiate receptors and mechanisms of arrhythmias. In: Bulletin of Experimental Biology and Medicine. 1999 ; Vol. 127, No. 1. pp. 50-52.

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