Cellular and molecular basis of osteoblastic and vascular niches in the processes of hematopoiesis and bone remodeling (A short review of modern views)

Kristina A. Yurova, Olga G. Khaziakhmatova, Elena S. Melashchenko, Vladimir V. Malashchenko, Egor O. Shunkin, Valeria V. Shupletsova, Pavel A. Ivanov, Igor A. Khlusov, Larisa S. Litvinova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In evolutionary processes, human bone marrow has formed as an organ depot of various types of cells that arise from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Vital HSC activity is controlled through molecular interactions with the niche microenvironment. The review describes current views on the formation of key molecular and cellular components of the HSC niche, which ensure maintenance of homeostasis in stem cell niches, obtained from studies of their role in regulating the proliferation and differentiation of HSCs, including the physiological, reparative and pathological remodeling of bone tissue. Due to rapid developments in biotechnology, tissue bioengineering, and regenerative medicine, information can be useful for developing biomimetic and bioinspired materials and implants that provide an effective bone/bone marrow recovery process after injuries and, to a greater extent, diseases of various etiologies.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalCurrent Pharmaceutical Design
Volume25
Issue number6
DOIs
Publication statusPublished - 2019

Keywords

  • Biomaterials
  • Bone marrow
  • Bone marrow niche
  • Extracellular matrix
  • Hematopoietic stem cells
  • Mesenchymal stem cells
  • Tissue remodeling

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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