Cells of mononuclear phagocytes system of liver and lung in rats after intravenous application of magnetite nanoparticles

I. V. Milto, I. V. Suhodolo, V. Yu Usov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The article describes changes in the morphology and localization of the cells of mononuclear phagocyte system of liver and lung in rats at different times after single and repeated intravenous administration of a suspension of nanoparticles of magnetite (NPM). Mechanisms for removal of nanoparticles of magnetite from the rat body with the participation of mononuclear phagocytes of the liver (removal of the particles by stellate macrophages in the gastroenteric tract with bile) and of the lung (by migration of the alveolar macrophages in the gleam of the bronchial tree) have been illustrated. It has been shown that intravenous application of nanomagnetite causes changes in the morphology of the internal organs of rats and the severity of these changes increases with increasing total dose injected magnetite.

Original languageEnglish
Pages (from-to)566-572
Number of pages7
JournalTsitologiya
Volume54
Issue number7
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Nanoparticles of magnetite
  • Stellate (Kupfer's cell) and alveolar macrophages

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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