Cation-chloride cotransporters: Regulation, physiological significance, and role in pathogenesis of arterial hypertension

S. N. Orlov, S. V. Koltsova, L. V. Kapilevich, N. O. Dulin, S. V. Gusakova

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na+,K+,2Cl- cotransport), potassium and chloride (K+,Cl- cotransport), and sodium and chloride (K+,Cl- cotransport) as well as molecular mechanisms of the regulation of these carriers and their physiological significance. We emphasized the involvement of chloride-coupled carriers in the regulation of cell volume and intracellular chloride concentration and novel data on the role of ubiquitous isoform of Na+,K+,2Cl- cotransporter NKCC1 in regulation of vascular smooth muscle contraction and activity of GABAA receptors. Finally, we analyzed the data on activation of NKCC1 in patients with essential hypertension and its role in the long-term maintenance of elevated systemic blood pressure and myogenic response in microcirculatory beds.

Original languageEnglish
Pages (from-to)1546-1561
Number of pages16
JournalBiochemistry (Moscow)
Volume79
Issue number13
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Potassium Chloride
Cations
Chlorides
Hypertension
Sodium Chloride
Member 2 Solute Carrier Family 12
Ion Transport
Blood pressure
GABA-A Receptors
Muscle Contraction
Cell Size
Vascular Smooth Muscle
Muscle
Protein Isoforms
Sodium
Chemical activation
Cells
Blood Pressure

Keywords

  • chloride
  • contraction
  • cotransport
  • hypertension
  • myogenic tone
  • potassium
  • smooth muscle
  • sodium
  • sympathetic nervous system

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

Cite this

Cation-chloride cotransporters : Regulation, physiological significance, and role in pathogenesis of arterial hypertension. / Orlov, S. N.; Koltsova, S. V.; Kapilevich, L. V.; Dulin, N. O.; Gusakova, S. V.

In: Biochemistry (Moscow), Vol. 79, No. 13, 2014, p. 1546-1561.

Research output: Contribution to journalReview article

Orlov, S. N. ; Koltsova, S. V. ; Kapilevich, L. V. ; Dulin, N. O. ; Gusakova, S. V. / Cation-chloride cotransporters : Regulation, physiological significance, and role in pathogenesis of arterial hypertension. In: Biochemistry (Moscow). 2014 ; Vol. 79, No. 13. pp. 1546-1561.
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