Cation-chloride cotransporters: Regulation, physiological significance, and role in pathogenesis of arterial hypertension

S. N. Orlov, S. V. Koltsova, L. V. Kapilevich, N. O. Dulin, S. V. Gusakova

Research output: Contribution to journalReview article

5 Citations (Scopus)


This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na+,K+,2Cl- cotransport), potassium and chloride (K+,Cl- cotransport), and sodium and chloride (K+,Cl- cotransport) as well as molecular mechanisms of the regulation of these carriers and their physiological significance. We emphasized the involvement of chloride-coupled carriers in the regulation of cell volume and intracellular chloride concentration and novel data on the role of ubiquitous isoform of Na+,K+,2Cl- cotransporter NKCC1 in regulation of vascular smooth muscle contraction and activity of GABAA receptors. Finally, we analyzed the data on activation of NKCC1 in patients with essential hypertension and its role in the long-term maintenance of elevated systemic blood pressure and myogenic response in microcirculatory beds.

Original languageEnglish
Pages (from-to)1546-1561
Number of pages16
JournalBiochemistry (Moscow)
Issue number13
Publication statusPublished - 2014
Externally publishedYes



  • chloride
  • contraction
  • cotransport
  • hypertension
  • myogenic tone
  • potassium
  • smooth muscle
  • sodium
  • sympathetic nervous system

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

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