Abstract
It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
| Original language | English |
|---|---|
| Pages (from-to) | 21-28 |
| Number of pages | 8 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 71 |
| Issue number | 2 |
| Publication status | Published - 2008 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. / Maslov, L. N.; Lishmanov, Yu B.; Barzakh, E. I.; Maksimov, I. V.; Vorozhtsova, I. N.; Bukhovets, I. L.; Minin, S. M.; Orlova, E. B.; Lavrov, A. G.; Ovchinnlkov, M. V.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 71, No. 2, 2008, p. 21-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
AU - Barzakh, E. I.
AU - Maksimov, I. V.
AU - Vorozhtsova, I. N.
AU - Bukhovets, I. L.
AU - Minin, S. M.
AU - Orlova, E. B.
AU - Lavrov, A. G.
AU - Ovchinnlkov, M. V.
PY - 2008
Y1 - 2008
N2 - It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
AB - It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
UR - http://www.scopus.com/inward/record.url?scp=44349156517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44349156517&partnerID=8YFLogxK
M3 - Article
VL - 71
SP - 21
EP - 28
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 2
ER -