Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation

L. N. Maslov, Yu B. Lishmanov, E. I. Barzakh, I. V. Maksimov, I. N. Vorozhtsova, I. L. Bukhovets, S. M. Minin, E. B. Orlova, A. G. Lavrov, M. V. Ovchinnlkov

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Abstract

It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume71
Issue number2
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Maslov, L. N., Lishmanov, Y. B., Barzakh, E. I., Maksimov, I. V., Vorozhtsova, I. N., Bukhovets, I. L., Minin, S. M., Orlova, E. B., Lavrov, A. G., & Ovchinnlkov, M. V. (2008). Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. Eksperimental'naya i Klinicheskaya Farmakologiya, 71(2), 21-28.