Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation

L. N. Maslov, Yu B. Lishmanov, E. I. Barzakh, I. V. Maksimov, I. N. Vorozhtsova, I. L. Bukhovets, S. M. Minin, E. B. Orlova, A. G. Lavrov, M. V. Ovchinnlkov

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1 Citation (Scopus)

Abstract

It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	71
Issue number	2
Publication status	Published - 2008

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. / Maslov, L. N.; Lishmanov, Yu B.; Barzakh, E. I.; Maksimov, I. V.; Vorozhtsova, I. N.; Bukhovets, I. L.; Minin, S. M.; Orlova, E. B.; Lavrov, A. G.; Ovchinnlkov, M. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 71, No. 2, 2008, p. 21-28.

Research output: Contribution to journal › Article › peer-review

Maslov, L. N. ; Lishmanov, Yu B. ; Barzakh, E. I. ; Maksimov, I. V. ; Vorozhtsova, I. N. ; Bukhovets, I. L. ; Minin, S. M. ; Orlova, E. B. ; Lavrov, A. G. ; Ovchinnlkov, M. V. / Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2008 ; Vol. 71, No. 2. pp. 21-28.

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title = "Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation",

abstract = "It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the {"}steal syndrome.{"} The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.",

author = "Maslov, {L. N.} and Lishmanov, {Yu B.} and Barzakh, {E. I.} and Maksimov, {I. V.} and Vorozhtsova, {I. N.} and Bukhovets, {I. L.} and Minin, {S. M.} and Orlova, {E. B.} and Lavrov, {A. G.} and Ovchinnlkov, {M. V.}",

year = "2008",

language = "English",

volume = "71",

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journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",

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T1 - Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Barzakh, E. I.

AU - Maksimov, I. V.

AU - Vorozhtsova, I. N.

AU - Bukhovets, I. L.

AU - Minin, S. M.

AU - Orlova, E. B.

AU - Lavrov, A. G.

AU - Ovchinnlkov, M. V.

PY - 2008

Y1 - 2008

N2 - It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.

AB - It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.

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JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

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Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation

Abstract

ASJC Scopus subject areas

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