It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
|Number of pages||8|
|Journal||Eksperimental'naya i Klinicheskaya Farmakologiya|
|Publication status||Published - 2008|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)