Abstract
It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
| Original language | English |
|---|---|
| Pages (from-to) | 21-28 |
| Number of pages | 8 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 71 |
| Issue number | 2 |
| Publication status | Published - 2008 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
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Maslov, L. N., Lishmanov, Y. B., Barzakh, E. I., Maksimov, I. V., Vorozhtsova, I. N., Bukhovets, I. L., Minin, S. M., Orlova, E. B., Lavrov, A. G., & Ovchinnlkov, M. V. (2008). Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. Eksperimental'naya i Klinicheskaya Farmakologiya, 71(2), 21-28.