Abstract
It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
Original language | English |
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Pages (from-to) | 21-28 |
Number of pages | 8 |
Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
Volume | 71 |
Issue number | 2 |
Publication status | Published - 2008 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)