Abstract
Immobilization induces stress damage to the heart. DAGO, an agonist of μ-opiate receptors potentiates, while an agonist of peripheral μ-opiate receptors prevents this damage. Naltrexone reduces, while methylnaltrexone, an inhibitor of peripheral μ-opiate receptors, potentiates the stress-induced damage to the heart. Other opiate ligands have no effect on heart damage. It is suggested that the stress-induced damage to the heart is promoted by activation of central μ-opiate receptors and prevented by stimulation of peripheral μ-opiate receptors.
Original language | English |
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Pages (from-to) | 239-241 |
Number of pages | 3 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 123 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1997 |
Keywords
- opiate-receptors
- stress-induced damage to the heart
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)