Abstract
Immobilization induces stress damage to the heart. DAGO, an agonist of μ-opiate receptors potentiates, while an agonist of peripheral μ-opiate receptors prevents this damage. Naltrexone reduces, while methylnaltrexone, an inhibitor of peripheral μ-opiate receptors, potentiates the stress-induced damage to the heart. Other opiate ligands have no effect on heart damage. It is suggested that the stress-induced damage to the heart is promoted by activation of central μ-opiate receptors and prevented by stimulation of peripheral μ-opiate receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 239-241 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 123 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1997 |
Keywords
- opiate-receptors
- stress-induced damage to the heart
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Lishmanov, Y. B., Maslov, L. N., & Naryzhnaya, N. V. (1997). Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage. Bulletin of Experimental Biology and Medicine, 123(3), 239-241. https://doi.org/10.1007/BF02445413