Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage

Yu B. Lishmanov, L. N. Maslov, N. V. Naryzhnaya

Research Nuclear Reactor Center

Research output: Contribution to journal › Article

Abstract

Immobilization induces stress damage to the heart. DAGO, an agonist of μ-opiate receptors potentiates, while an agonist of peripheral μ-opiate receptors prevents this damage. Naltrexone reduces, while methylnaltrexone, an inhibitor of peripheral μ-opiate receptors, potentiates the stress-induced damage to the heart. Other opiate ligands have no effect on heart damage. It is suggested that the stress-induced damage to the heart is promoted by activation of central μ-opiate receptors and prevented by stimulation of peripheral μ-opiate receptors.

Original language	English
Pages (from-to)	239-241
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	123
Issue number	3
DOIs	https://doi.org/10.1007/BF02445413
Publication status	Published - Mar 1997

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Opioid Receptors

Opiate Alkaloids

Ala(2)-MePhe(4)-Gly(5)-enkephalin

Naltrexone

Immobilization

Chemical activation

Ligands

Keywords

opiate-receptors
stress-induced damage to the heart

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lishmanov, Y. B., Maslov, L. N., & Naryzhnaya, N. V. (1997). Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage. Bulletin of Experimental Biology and Medicine, 123(3), 239-241. https://doi.org/10.1007/BF02445413

Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage. / Lishmanov, Yu B.; Maslov, L. N.; Naryzhnaya, N. V.

In: Bulletin of Experimental Biology and Medicine, Vol. 123, No. 3, 03.1997, p. 239-241.

Research output: Contribution to journal › Article

Lishmanov, YB, Maslov, LN & Naryzhnaya, NV 1997, 'Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage', Bulletin of Experimental Biology and Medicine, vol. 123, no. 3, pp. 239-241. https://doi.org/10.1007/BF02445413

Lishmanov YB, Maslov LN, Naryzhnaya NV. Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage. Bulletin of Experimental Biology and Medicine. 1997 Mar;123(3):239-241. https://doi.org/10.1007/BF02445413

Lishmanov, Yu B. ; Maslov, L. N. ; Naryzhnaya, N. V. / Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage. In: Bulletin of Experimental Biology and Medicine. 1997 ; Vol. 123, No. 3. pp. 239-241.

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Access to Document

10.1007/BF02445413