Cardioprotective effect of remote postconditioning: Mechanisms and possibility of clinical application

Yu B. Lishmanov, L. N. Maslov, A. G. Mrochek, A. V. Gourine

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Experimental data indicate that postconditioning at distance is an effective method of cardiac protection against reperfusion injury. Remote postconditioning prevents reperfusion necrosis and apoptosis of cardiomyocytes, decreases probability of postinfarction remodeling of the heart. Cardioprotective effect of remote postconditioning is depended on release from tissues after transient ischemia of humoral factor(s) increasing cardiac tolerance to long-term ischemia-reperfusion. Clinical studies show that postconditioning at distance is an effective method of prevention of reperfusion injury of the heart during coronary artery bypass surgery.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalKardiologiya
Volume53
Issue number9
Publication statusPublished - 2013

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Keywords

  • Heart
  • Ischemia
  • Remote postconditioning
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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