Cardioprotective effect of ischemic postconditioning on the model of isolated heart

L. N. Maslov, A. S. Gorbunov, Y. B Yu B Lishmanov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Irreversible cardiomyocyte damage was induced by 45-min global ischemia followed by 30- min reperfusion in Langendorff-perfused isolated rat heart. Cell damage was assessed by the release of creatine phosphokinase into the perfusate. The hearts were subjected to the following postconditioning protocols: 1) three cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 2) six cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 3) three sessions of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 4) 6 cycles of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 5) 3 cycles of 30-sec reperfusion and 30-sec ischemia, total cycle time 60 sec. It was found that only postconditioning with a total cycle time of 40 sec or 60 sec prevents myocardial reperfusion injury.

Original languageEnglish
Pages (from-to)313-314
Number of pages2
JournalBulletin of Experimental Biology and Medicine
Volume153
Issue number3
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Heart
  • Ischemia
  • Postconditioning
  • Reperfusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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