Abstract
Irreversible cardiomyocyte damage was induced by 45-min global ischemia followed by 30- min reperfusion in Langendorff-perfused isolated rat heart. Cell damage was assessed by the release of creatine phosphokinase into the perfusate. The hearts were subjected to the following postconditioning protocols: 1) three cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 2) six cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 3) three sessions of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 4) 6 cycles of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 5) 3 cycles of 30-sec reperfusion and 30-sec ischemia, total cycle time 60 sec. It was found that only postconditioning with a total cycle time of 40 sec or 60 sec prevents myocardial reperfusion injury.
| Original language | English |
|---|---|
| Pages (from-to) | 313-314 |
| Number of pages | 2 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 153 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 2012 |
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Keywords
- Heart
- Ischemia
- Postconditioning
- Reperfusion
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Cardioprotective effect of ischemic postconditioning on the model of isolated heart. / Maslov, L. N.; Gorbunov, A. S.; Lishmanov, Y. B Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 153, No. 3, 07.2012, p. 313-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardioprotective effect of ischemic postconditioning on the model of isolated heart
AU - Maslov, L. N.
AU - Gorbunov, A. S.
AU - Lishmanov, Y. B Yu B
PY - 2012/7
Y1 - 2012/7
N2 - Irreversible cardiomyocyte damage was induced by 45-min global ischemia followed by 30- min reperfusion in Langendorff-perfused isolated rat heart. Cell damage was assessed by the release of creatine phosphokinase into the perfusate. The hearts were subjected to the following postconditioning protocols: 1) three cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 2) six cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 3) three sessions of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 4) 6 cycles of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 5) 3 cycles of 30-sec reperfusion and 30-sec ischemia, total cycle time 60 sec. It was found that only postconditioning with a total cycle time of 40 sec or 60 sec prevents myocardial reperfusion injury.
AB - Irreversible cardiomyocyte damage was induced by 45-min global ischemia followed by 30- min reperfusion in Langendorff-perfused isolated rat heart. Cell damage was assessed by the release of creatine phosphokinase into the perfusate. The hearts were subjected to the following postconditioning protocols: 1) three cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 2) six cycles of 10-sec reperfusion and 10-sec ischemia, total cycle time 20 sec; 3) three sessions of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 4) 6 cycles of 20-sec reperfusion and 20-sec ischemia, total cycle time 40 sec; 5) 3 cycles of 30-sec reperfusion and 30-sec ischemia, total cycle time 60 sec. It was found that only postconditioning with a total cycle time of 40 sec or 60 sec prevents myocardial reperfusion injury.
KW - Heart
KW - Ischemia
KW - Postconditioning
KW - Reperfusion
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U2 - 10.1007/s10517-012-1703-y
DO - 10.1007/s10517-012-1703-y
M3 - Article
C2 - 22866299
VL - 153
SP - 313
EP - 314
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 3
ER -