Cardioprotective effect of emoxipine in reconstructive coronary artery surgery

A. M. Chernyavsky, L. N. Maslov, I. V. Ponomarenko, Yu Yu Vechersky, Yu B. Lishmanov, R. S. Karpov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of the study was to evaluate possible protective effect of chlorhydrate-3-ethyl-6-methyl-3-oxypiridin (emoxipine) during myocardial ischemia/reperfusion. Prior to coronary artery surgery 27 patients were randomized into 2 groups: 15 patients in 1 hour before operation received rapid intravenous infusion of emoxipine (10 ml of 3% solution) and 12 patients received infusion of placebo. Lipid peroxide concentrations; CR-MB activity and frequency of arrhythmia were evaluated. Immediately after termination of extracorporeal circulation emoxipine treated compared to placebo treated patients had lower levels of malonic dialdehyde and dienic conjugates (10,4±0,8 vs 14,9±1,5 nmol/l and 4,4±0,5 vs 5,9±0,4 nmol/l, p<0,05). Frequency of arrhythmia (25% and 47%) and defibrillation threshold (12,1±3,1 and 29,3±4,2 J, p<0,01) were also lower in emoxipine treated patients. These data indicated that emoxipine prodiced protective effect against reperfusion injury of the myocardium during open heart surgery.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalKardiologiya
Volume36
Issue number8
Publication statusPublished - 1 Dec 1996

Fingerprint

Coronary Vessels
Cardiac Arrhythmias
Placebos
Myocardial Reperfusion
Extracorporeal Circulation
Lipid Peroxides
Reperfusion Injury
Intravenous Infusions
Thoracic Surgery
Myocardial Ischemia
Myocardium
6-methyl-2-ethyl-3-hydroxypyridine

Keywords

  • Coronary artery bypass grafting
  • Emoxipine
  • Myocardial reperfusion injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chernyavsky, A. M., Maslov, L. N., Ponomarenko, I. V., Vechersky, Y. Y., Lishmanov, Y. B., & Karpov, R. S. (1996). Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. Kardiologiya, 36(8), 35-38.

Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. / Chernyavsky, A. M.; Maslov, L. N.; Ponomarenko, I. V.; Vechersky, Yu Yu; Lishmanov, Yu B.; Karpov, R. S.

In: Kardiologiya, Vol. 36, No. 8, 01.12.1996, p. 35-38.

Research output: Contribution to journalArticle

Chernyavsky, AM, Maslov, LN, Ponomarenko, IV, Vechersky, YY, Lishmanov, YB & Karpov, RS 1996, 'Cardioprotective effect of emoxipine in reconstructive coronary artery surgery', Kardiologiya, vol. 36, no. 8, pp. 35-38.
Chernyavsky AM, Maslov LN, Ponomarenko IV, Vechersky YY, Lishmanov YB, Karpov RS. Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. Kardiologiya. 1996 Dec 1;36(8):35-38.
Chernyavsky, A. M. ; Maslov, L. N. ; Ponomarenko, I. V. ; Vechersky, Yu Yu ; Lishmanov, Yu B. ; Karpov, R. S. / Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. In: Kardiologiya. 1996 ; Vol. 36, No. 8. pp. 35-38.
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