Cardioprotective effect of emoxipine in reconstructive coronary artery surgery

A. M. Chernyavsky, L. N. Maslov, I. V. Ponomarenko, Yu Yu Vechersky, Yu B. Lishmanov, R. S. Karpov

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Abstract

The purpose of the study was to evaluate possible protective effect of chlorhydrate-3-ethyl-6-methyl-3-oxypiridin (emoxipine) during myocardial ischemia/reperfusion. Prior to coronary artery surgery 27 patients were randomized into 2 groups: 15 patients in 1 hour before operation received rapid intravenous infusion of emoxipine (10 ml of 3% solution) and 12 patients received infusion of placebo. Lipid peroxide concentrations; CR-MB activity and frequency of arrhythmia were evaluated. Immediately after termination of extracorporeal circulation emoxipine treated compared to placebo treated patients had lower levels of malonic dialdehyde and dienic conjugates (10,4±0,8 vs 14,9±1,5 nmol/l and 4,4±0,5 vs 5,9±0,4 nmol/l, p<0,05). Frequency of arrhythmia (25% and 47%) and defibrillation threshold (12,1±3,1 and 29,3±4,2 J, p<0,01) were also lower in emoxipine treated patients. These data indicated that emoxipine prodiced protective effect against reperfusion injury of the myocardium during open heart surgery.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalKardiologiya
Volume36
Issue number8
Publication statusPublished - 1 Dec 1996

Keywords

  • Coronary artery bypass grafting
  • Emoxipine
  • Myocardial reperfusion injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Chernyavsky, A. M., Maslov, L. N., Ponomarenko, I. V., Vechersky, Y. Y., Lishmanov, Y. B., & Karpov, R. S. (1996). Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. Kardiologiya, 36(8), 35-38.