Abstract
The purpose of the study was to evaluate possible protective effect of chlorhydrate-3-ethyl-6-methyl-3-oxypiridin (emoxipine) during myocardial ischemia/reperfusion. Prior to coronary artery surgery 27 patients were randomized into 2 groups: 15 patients in 1 hour before operation received rapid intravenous infusion of emoxipine (10 ml of 3% solution) and 12 patients received infusion of placebo. Lipid peroxide concentrations; CR-MB activity and frequency of arrhythmia were evaluated. Immediately after termination of extracorporeal circulation emoxipine treated compared to placebo treated patients had lower levels of malonic dialdehyde and dienic conjugates (10,4±0,8 vs 14,9±1,5 nmol/l and 4,4±0,5 vs 5,9±0,4 nmol/l, p<0,05). Frequency of arrhythmia (25% and 47%) and defibrillation threshold (12,1±3,1 and 29,3±4,2 J, p<0,01) were also lower in emoxipine treated patients. These data indicated that emoxipine prodiced protective effect against reperfusion injury of the myocardium during open heart surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 35-38 |
| Number of pages | 4 |
| Journal | Kardiologiya |
| Volume | 36 |
| Issue number | 8 |
| Publication status | Published - 1 Dec 1996 |
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Keywords
- Coronary artery bypass grafting
- Emoxipine
- Myocardial reperfusion injury
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Cardioprotective effect of emoxipine in reconstructive coronary artery surgery. / Chernyavsky, A. M.; Maslov, L. N.; Ponomarenko, I. V.; Vechersky, Yu Yu; Lishmanov, Yu B.; Karpov, R. S.
In: Kardiologiya, Vol. 36, No. 8, 01.12.1996, p. 35-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardioprotective effect of emoxipine in reconstructive coronary artery surgery
AU - Chernyavsky, A. M.
AU - Maslov, L. N.
AU - Ponomarenko, I. V.
AU - Vechersky, Yu Yu
AU - Lishmanov, Yu B.
AU - Karpov, R. S.
PY - 1996/12/1
Y1 - 1996/12/1
N2 - The purpose of the study was to evaluate possible protective effect of chlorhydrate-3-ethyl-6-methyl-3-oxypiridin (emoxipine) during myocardial ischemia/reperfusion. Prior to coronary artery surgery 27 patients were randomized into 2 groups: 15 patients in 1 hour before operation received rapid intravenous infusion of emoxipine (10 ml of 3% solution) and 12 patients received infusion of placebo. Lipid peroxide concentrations; CR-MB activity and frequency of arrhythmia were evaluated. Immediately after termination of extracorporeal circulation emoxipine treated compared to placebo treated patients had lower levels of malonic dialdehyde and dienic conjugates (10,4±0,8 vs 14,9±1,5 nmol/l and 4,4±0,5 vs 5,9±0,4 nmol/l, p<0,05). Frequency of arrhythmia (25% and 47%) and defibrillation threshold (12,1±3,1 and 29,3±4,2 J, p<0,01) were also lower in emoxipine treated patients. These data indicated that emoxipine prodiced protective effect against reperfusion injury of the myocardium during open heart surgery.
AB - The purpose of the study was to evaluate possible protective effect of chlorhydrate-3-ethyl-6-methyl-3-oxypiridin (emoxipine) during myocardial ischemia/reperfusion. Prior to coronary artery surgery 27 patients were randomized into 2 groups: 15 patients in 1 hour before operation received rapid intravenous infusion of emoxipine (10 ml of 3% solution) and 12 patients received infusion of placebo. Lipid peroxide concentrations; CR-MB activity and frequency of arrhythmia were evaluated. Immediately after termination of extracorporeal circulation emoxipine treated compared to placebo treated patients had lower levels of malonic dialdehyde and dienic conjugates (10,4±0,8 vs 14,9±1,5 nmol/l and 4,4±0,5 vs 5,9±0,4 nmol/l, p<0,05). Frequency of arrhythmia (25% and 47%) and defibrillation threshold (12,1±3,1 and 29,3±4,2 J, p<0,01) were also lower in emoxipine treated patients. These data indicated that emoxipine prodiced protective effect against reperfusion injury of the myocardium during open heart surgery.
KW - Coronary artery bypass grafting
KW - Emoxipine
KW - Myocardial reperfusion injury
UR - http://www.scopus.com/inward/record.url?scp=3342896567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3342896567&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 35
EP - 38
JO - Kardiologiya
JF - Kardiologiya
SN - 0022-9040
IS - 8
ER -