Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization

T. V. Lasukova, L. N. Maslov, A. A. Platonov, N. V. Guzarova, Yu B. Lishmanov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cardioprotective and antiarrhythmic effects of a selective β1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 μM inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 μM. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 μM produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume143
Issue number1
DOIs
Publication statusPublished - 1 Jan 2007

Fingerprint

Opioid Receptors
Reperfusion
Chemical activation
Creatine Kinase
Opioid Analgesics
Rats
Cardiac Myocytes
Cardiac Arrhythmias
Myocardium
Ischemia
Incidence

Keywords

  • β-opioidreceptors
  • cAMP
  • Ischemia-reperfusion
  • Isolated perfused heart

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization. / Lasukova, T. V.; Maslov, L. N.; Platonov, A. A.; Guzarova, N. V.; Lishmanov, Yu B.

In: Bulletin of Experimental Biology and Medicine, Vol. 143, No. 1, 01.01.2007, p. 22-25.

Research output: Contribution to journalArticle

Lasukova, T. V. ; Maslov, L. N. ; Platonov, A. A. ; Guzarova, N. V. ; Lishmanov, Yu B. / Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization. In: Bulletin of Experimental Biology and Medicine. 2007 ; Vol. 143, No. 1. pp. 22-25.
@article{b71e54875e774a068131e224e13fbb7d,
title = "Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization",
abstract = "The cardioprotective and antiarrhythmic effects of a selective β1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 μM inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 μM. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 μM produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.",
keywords = "β-opioidreceptors, cAMP, Ischemia-reperfusion, Isolated perfused heart",
author = "Lasukova, {T. V.} and Maslov, {L. N.} and Platonov, {A. A.} and Guzarova, {N. V.} and Lishmanov, {Yu B.}",
year = "2007",
month = "1",
day = "1",
doi = "10.1007/s10517-007-0007-0",
language = "English",
volume = "143",
pages = "22--25",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization

AU - Lasukova, T. V.

AU - Maslov, L. N.

AU - Platonov, A. A.

AU - Guzarova, N. V.

AU - Lishmanov, Yu B.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The cardioprotective and antiarrhythmic effects of a selective β1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 μM inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 μM. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 μM produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.

AB - The cardioprotective and antiarrhythmic effects of a selective β1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 μM inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 μM. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 μM produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.

KW - β-opioidreceptors

KW - cAMP

KW - Ischemia-reperfusion

KW - Isolated perfused heart

UR - http://www.scopus.com/inward/record.url?scp=34249042097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249042097&partnerID=8YFLogxK

U2 - 10.1007/s10517-007-0007-0

DO - 10.1007/s10517-007-0007-0

M3 - Article

VL - 143

SP - 22

EP - 25

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -