Cardioprotective effect of κ1-opioid receptor activation and role of cAMP in its realization

T. V. Lasukova, L. N. Maslov, A. A. Platonov, N. V. Guzarova, Yu B. Lishmanov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cardioprotective and antiarrhythmic effects of a selective β1-opioid receptor agonist U-50,488 were studied during experimental 45-min total ischemia and 30-min reperfusion of isolated rat heart. The opioid had no effect on the incidence and type of reperfusion arrhythmias. U-50,488 in a concentration of 0.1 μM inhibited reperfusion-induced release of creatine phosphokinase and decreased cAMP concentration in the myocardium by 2 times. These parameters remained unchanged after treatment with U-50,488 in a concentration of 1 μM. The cardioprotective effect of U-50,488 was probably associated with a decrease in cAMP concentration in heart cells. U-50,488 in a concentration of 1 μM produced no cardioprotective effect, which can be explained by its interaction with an unknown non-opioid receptor in cardiomyocytes.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume143
Issue number1
DOIs
Publication statusPublished - 1 Jan 2007

Keywords

  • β-opioidreceptors
  • cAMP
  • Ischemia-reperfusion
  • Isolated perfused heart

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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