Cancer gene therapy with plasmid expressing anti-HER2/neu-Toxin

Yu M. Khodarovich, D. D. Rakhmaninova, G. O. Kagarlitskiy, S. M. Deev

Research output: Contribution to journalArticlepeer-review

Abstract

The HER2/neu receptor is over-expressed on the surface of many types of cancer cells, and is widely used for targeted delivery of anticancer drugs. We have created genetically engineered construct expressing the PE40 fragment of Pseudomonas toxin bound with the DARPin molecule which recognizes the HER2/neu receptor with high specificity. The construct destroyed transfected tumor cells in vitro. Intra-Tumor injections of the construct complexed with polyethyleneimine led to growth retardation of D2F2/E2 tumors in mice. These results suggest a possibility of using this approach to develop new anticancer drugs.

Original languageEnglish
Pages (from-to)671-675
Number of pages5
JournalVoprosy Onkologii
Volume62
Issue number5
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Darpin
  • Gene therapy
  • HER2/NEU receptor
  • Pseudomonas exotoxin a
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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