Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement

Paulius Danilevicius, Rodrigo A. Rezende, Frederico D.A.S. Pereira, Alexandros Selimis, Vladimir Kasyanov, Pedro Y. Noritomi, Jorge V.L. da Silva, Maria Chatzinikolaidou, Maria Farsari, Vladimir Mironov

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher®. They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.

Original languageEnglish
Article number021011
Issue number2
Publication statusPublished - 1 Jun 2015
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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