Bone implant surfaces designed for in situ Bmp-2 delivery and targeted implant integration

Herbert P. Jennissen, Maria Chatzinikolaidou

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The retaining of biological activity of the immobilization bone morphogenetic proteins (BMP-2) was demonstrated in vitro and in vivo. The plasma spray coated titanium-alloy cylinders were also silanized with aminopropyltriethoxy silane (APS) and rhBMP-2 was adsorbed in an amount of ∼ 5μg/cm2. The biological activity of rhBMP-2 was measured by induction of alkaline phosphatase in MC3T3- E1 cells either employing p-nitrophenyl phosphate or ELF-97 as substrates. The results confirmed in vivo by employing a gap-healing model in the distal femur condylus of sheep.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)

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