Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs

Jürgen Becker, Axel Kirsch, Frank Schwarz, Maria Chatzinikolaidou, Daniel Rothamel, Vojislav Lekovic, Herbert Peter Jennissen

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

The aim of the present study was to investigate bone formation to recombinant human bone morphogenetic protein-2 (rhBMP-2)-biocoated and rhBMP-2-nonbiocoated titanium implants after implantation in dogs. Implantation of sand-blasted and acid-etched (C), chromosulfuric acid surface-enhanced (CSA), and rhBMP-2-biocoated CSA [BMP-A: noncovalently immobilized rhBMP-2 (596 ng/cm2), BMP-B: covalently immobilized rhBMP-2 (819 ng/cm2)] implants was performed in both the mandible and tibia of dogs. After 4 weeks of healing, the percentage of direct bone to implant contact (BIC) and the induced bone density (BD) at a distance of less than and greater than 1 mm adjacent to each implant was assessed. Histomorphometric analysis of implants inserted in the mandible and tibia revealed that BIC values appeared to be highest in the BMP-B group, followed by BMP-A, CSA, and C. BD as measured at a distance of <1 mm revealed obvious differences between groups: BMP-B>BMP-A>CSA>C. However, no differences between groups were observed at a distance of >1 mm. Within the limits of the present study, it may be concluded that rhBMP-2 immobilized by covalent and noncovalent methods on CSA-treated implant surfaces seemed to be stable and promoted direct bone apposition in a concentration-dependant manner.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalClinical Oral Investigations
Volume10
Issue number3
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Keywords

  • Animal study
  • Bioactive surface
  • rhBMP-2
  • Titanium implant
  • Ultrahydrophilic surface

ASJC Scopus subject areas

  • Dentistry(all)

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