Bioreactor-based tumor tissue engineering

A. E. Guller, P. N. Grebenyuk, A. B. Shekhter, A. V. Zvyagin, S. M. Deyev

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

© 2016 Park-media, Ltd. This review focuses on modeling of cancer tumors using tissue engineering technology. Tumor tissue engineering (TTE) is a new method of three-dimensional (3D) simulation of malignant neoplasms. Design and development of complex tissue engineering constructs (TECs) that include cancer cells, cell-bearing scaffolds acting as the extracellular matrix, and other components of the tumor microenvironment is at the core of this approach. Although TECs can be transplanted into laboratory animals, the specific aim of TTE is the most realistic reproduction and long-term maintenance of the simulated tumor properties in vitro for cancer biology research and for the development of new methods of diagnosis and treatment of malignant neoplasms. Successful implementation of this challenging idea depends on bioreactor technology, which will enable optimization of culture conditions and control of tumor TECs development. In this review, we analyze the most popular bioreactor types in TTE and the emerging applications.
Original languageEnglish
Pages (from-to)44-58
Number of pages15
JournalActa Naturae
Volume8
Issue number3
Publication statusPublished - 1 Jan 2016

Fingerprint

Bioreactors
Tissue Engineering
Tissue engineering
Tumors
Neoplasms
Bearings (structural)
Engineering technology
Scaffolds
Technology
Animals
Tumor Microenvironment
Cells
Laboratory Animals
Extracellular Matrix
Reproduction

Keywords

  • Bioreactors
  • Cancer
  • Models
  • Tissue engineering

Cite this

Guller, A. E., Grebenyuk, P. N., Shekhter, A. B., Zvyagin, A. V., & Deyev, S. M. (2016). Bioreactor-based tumor tissue engineering. Acta Naturae, 8(3), 44-58.

Bioreactor-based tumor tissue engineering. / Guller, A. E.; Grebenyuk, P. N.; Shekhter, A. B.; Zvyagin, A. V.; Deyev, S. M.

In: Acta Naturae, Vol. 8, No. 3, 01.01.2016, p. 44-58.

Research output: Contribution to journalReview article

Guller, AE, Grebenyuk, PN, Shekhter, AB, Zvyagin, AV & Deyev, SM 2016, 'Bioreactor-based tumor tissue engineering', Acta Naturae, vol. 8, no. 3, pp. 44-58.
Guller AE, Grebenyuk PN, Shekhter AB, Zvyagin AV, Deyev SM. Bioreactor-based tumor tissue engineering. Acta Naturae. 2016 Jan 1;8(3):44-58.
Guller, A. E. ; Grebenyuk, P. N. ; Shekhter, A. B. ; Zvyagin, A. V. ; Deyev, S. M. / Bioreactor-based tumor tissue engineering. In: Acta Naturae. 2016 ; Vol. 8, No. 3. pp. 44-58.
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