Bioinspired Spiky Peroxidase-Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

Ye Yang, Xizheng Wu, Lang Ma, Chao He, Sujiao Cao, Yanping Long, Jianbo Huang, Raul D. Rodriguez, Chong Cheng, Changsheng Zhao, Li Qiu

Research output: Contribution to journalArticlepeer-review

Abstract

Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad-spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus-like peroxidase-mimic (V-POD-M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal–organic-framework-derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3, can serve as a peroxo-complex-intermediate to reduce the free energy for catalyzing H2O2, which mainly benefits the generation of •OH radicals. The unique virus-like spikes endow the V-POD-M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL–1). Furthermore, the in vivo experiments show that V-POD-M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V-POD-M provides a promising broad-spectrum therapy for nonantibiotic disinfection.

Original languageEnglish
Article number2005477
JournalAdvanced Materials
Volume33
Issue number8
DOIs
Publication statusPublished - 24 Feb 2021

Keywords

  • bacterial capture
  • catalytic ROS generation
  • peroxidase-mimics and biomimetics
  • virus-like nanostructures
  • wound disinfection

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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