Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of mössbauer and magnetization data

Raul Gabbasov, Valery Cherepanov, Mikhail Chuev, Mikhail Polikarpov, Maxim Nikitin, Sergey Deyev, Vladislav Panchenko

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The potential of Mössbauer spectroscopy to study the biodegradation process of magnetic nanoparticles in vivo was demonstrated. Magnetic nanoparticles in form of ferrofluid were administrated to mice. The Mössbauer study of the mice liver samples has shown that in addition to the sextet of lines related to the injected nanoparticles there appears an intense doublet of lines in the spectra with increasing times after the particles administration. Further analysis showed that the doublet consists of two components related to the formation of iron-containing proteins and superparamagnetic behavior of the injected nanoparticles. Using combined analysis of three Mössbauer spectra taken at different external conditions and magnetization curves measured for each sample these components were separated and the evolution with time of each component was characterized.

Original languageEnglish
Article number6392369
Pages (from-to)394-397
Number of pages4
JournalIEEE Transactions on Magnetics
Volume49
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Biodegradation
Liver
Magnetization
Nanoparticles
Magnetic fluids
Iron
Spectroscopy
Proteins

Keywords

  • Biodegradation
  • magnetic nanoparticles
  • magnetization curves
  • Mössbauer spectroscopy
  • multilevel model
  • relaxation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

Cite this

Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of mössbauer and magnetization data. / Gabbasov, Raul; Cherepanov, Valery; Chuev, Mikhail; Polikarpov, Mikhail; Nikitin, Maxim; Deyev, Sergey; Panchenko, Vladislav.

In: IEEE Transactions on Magnetics, Vol. 49, No. 1, 6392369, 2013, p. 394-397.

Research output: Contribution to journalArticle

Gabbasov, Raul ; Cherepanov, Valery ; Chuev, Mikhail ; Polikarpov, Mikhail ; Nikitin, Maxim ; Deyev, Sergey ; Panchenko, Vladislav. / Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of mössbauer and magnetization data. In: IEEE Transactions on Magnetics. 2013 ; Vol. 49, No. 1. pp. 394-397.
@article{43c66640f34d40a1a836df684bb3533c,
title = "Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of m{\"o}ssbauer and magnetization data",
abstract = "The potential of M{\"o}ssbauer spectroscopy to study the biodegradation process of magnetic nanoparticles in vivo was demonstrated. Magnetic nanoparticles in form of ferrofluid were administrated to mice. The M{\"o}ssbauer study of the mice liver samples has shown that in addition to the sextet of lines related to the injected nanoparticles there appears an intense doublet of lines in the spectra with increasing times after the particles administration. Further analysis showed that the doublet consists of two components related to the formation of iron-containing proteins and superparamagnetic behavior of the injected nanoparticles. Using combined analysis of three M{\"o}ssbauer spectra taken at different external conditions and magnetization curves measured for each sample these components were separated and the evolution with time of each component was characterized.",
keywords = "Biodegradation, magnetic nanoparticles, magnetization curves, M{\"o}ssbauer spectroscopy, multilevel model, relaxation",
author = "Raul Gabbasov and Valery Cherepanov and Mikhail Chuev and Mikhail Polikarpov and Maxim Nikitin and Sergey Deyev and Vladislav Panchenko",
year = "2013",
doi = "10.1109/TMAG.2012.2226148",
language = "English",
volume = "49",
pages = "394--397",
journal = "IEEE Transactions on Magnetics",
issn = "0018-9464",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "1",

}

TY - JOUR

T1 - Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of mössbauer and magnetization data

AU - Gabbasov, Raul

AU - Cherepanov, Valery

AU - Chuev, Mikhail

AU - Polikarpov, Mikhail

AU - Nikitin, Maxim

AU - Deyev, Sergey

AU - Panchenko, Vladislav

PY - 2013

Y1 - 2013

N2 - The potential of Mössbauer spectroscopy to study the biodegradation process of magnetic nanoparticles in vivo was demonstrated. Magnetic nanoparticles in form of ferrofluid were administrated to mice. The Mössbauer study of the mice liver samples has shown that in addition to the sextet of lines related to the injected nanoparticles there appears an intense doublet of lines in the spectra with increasing times after the particles administration. Further analysis showed that the doublet consists of two components related to the formation of iron-containing proteins and superparamagnetic behavior of the injected nanoparticles. Using combined analysis of three Mössbauer spectra taken at different external conditions and magnetization curves measured for each sample these components were separated and the evolution with time of each component was characterized.

AB - The potential of Mössbauer spectroscopy to study the biodegradation process of magnetic nanoparticles in vivo was demonstrated. Magnetic nanoparticles in form of ferrofluid were administrated to mice. The Mössbauer study of the mice liver samples has shown that in addition to the sextet of lines related to the injected nanoparticles there appears an intense doublet of lines in the spectra with increasing times after the particles administration. Further analysis showed that the doublet consists of two components related to the formation of iron-containing proteins and superparamagnetic behavior of the injected nanoparticles. Using combined analysis of three Mössbauer spectra taken at different external conditions and magnetization curves measured for each sample these components were separated and the evolution with time of each component was characterized.

KW - Biodegradation

KW - magnetic nanoparticles

KW - magnetization curves

KW - Mössbauer spectroscopy

KW - multilevel model

KW - relaxation

UR - http://www.scopus.com/inward/record.url?scp=84871840276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871840276&partnerID=8YFLogxK

U2 - 10.1109/TMAG.2012.2226148

DO - 10.1109/TMAG.2012.2226148

M3 - Article

VL - 49

SP - 394

EP - 397

JO - IEEE Transactions on Magnetics

JF - IEEE Transactions on Magnetics

SN - 0018-9464

IS - 1

M1 - 6392369

ER -