Biodegradation of magnetic nanoparticles in mouse liver from combined analysis of mössbauer and magnetization data

Raul Gabbasov, Valery Cherepanov, Mikhail Chuev, Mikhail Polikarpov, Maxim Nikitin, Sergey Deyev, Vladislav Panchenko

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22 Citations (Scopus)

Abstract

The potential of Mössbauer spectroscopy to study the biodegradation process of magnetic nanoparticles in vivo was demonstrated. Magnetic nanoparticles in form of ferrofluid were administrated to mice. The Mössbauer study of the mice liver samples has shown that in addition to the sextet of lines related to the injected nanoparticles there appears an intense doublet of lines in the spectra with increasing times after the particles administration. Further analysis showed that the doublet consists of two components related to the formation of iron-containing proteins and superparamagnetic behavior of the injected nanoparticles. Using combined analysis of three Mössbauer spectra taken at different external conditions and magnetization curves measured for each sample these components were separated and the evolution with time of each component was characterized.

Original languageEnglish
Article number6392369
Pages (from-to)394-397
Number of pages4
JournalIEEE Transactions on Magnetics
Volume49
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Keywords

  • Biodegradation
  • magnetic nanoparticles
  • magnetization curves
  • Mössbauer spectroscopy
  • multilevel model
  • relaxation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

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