Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins

J. Ma, J. Meng, M. Simonet, N. Stingelin, T. Peijs, G. B. Sukhorukov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new type of biodegradable drug-loaded fibre scaffold has been successfully produced for the benefit of water-soluble drugs and proteins. Model drug loaded calcium carbonate (CaCO3) microparticles incorporated into poly(lactic acid-co-glycolic acid) (PLGA) fibres were manufactured by co-precipitation of CaCO3 and the drug molecules, followed by electrospinning of a suspension of such drug-loaded microparticles in a PLGA solution. Rhodamine 6G and bovine serum albumin were used as model drugs for our release study, representing small bioactive molecules and protein, respectively. A bead and string structure of fibres was achieved. The drug release was investigated with different drug loadings and in different pH release mediums. Results showed that a slow and sustained drug release was achieved in 40 days and the CaCO3 microparticles used as the second barrier restrained the initial burst release.

Original languageEnglish
Article number205
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number7
DOIs
Publication statusPublished - 21 Jul 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

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