TY - JOUR
T1 - Biodegradable defined shaped printed polymer microcapsules for drug delivery
AU - Kudryavtseva, Valeriya
AU - Boi, Stefania
AU - Read, Jordan
AU - Guillemet, Raphael
AU - Zhang, Jiaxin
AU - Udalov, Andrei
AU - Shesterikov, Evgeny
AU - Tverdokhlebov, Sergei
AU - Pastorino, Laura
AU - Gould, David J.
AU - Sukhorukov, Gleb B.
N1 - Funding Information:
This research received funding from the European Union within the OYSTER projects, Grant agreement no. 760827, Versus Arthritis Project Grant (21210) - Sustained and Controllable Local Delivery of Anti-inflammatory Therapeutics with Nanoengineered Microcapsules and supported by Tomsk Polytechnic University Competitiveness Enhancement Program project VIU-SEC B.P. Veinberg-196/2020.
Publisher Copyright:
©
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/20
Y1 - 2021/1/20
N2 - This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core-shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small water-soluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.
AB - This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core-shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small water-soluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.
KW - drug delivery
KW - microprinting
KW - polylactic acid
KW - polymer capsules
KW - soft lithography
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U2 - 10.1021/acsami.0c21607
DO - 10.1021/acsami.0c21607
M3 - Article
C2 - 33404209
AN - SCOPUS:85099645075
VL - 13
SP - 2371
EP - 2381
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 2
ER -