Biocomputing based on particle disassembly

Maxim P. Nikitin, Victoria O. Shipunova, Sergey M. Deyev, Petr I. Nikitin

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Nanoparticles with biocomputing capabilities could potentially be used to create sophisticated robotic devices with a variety of biomedical applications, including intelligent sensors and theranostic agents. DNA/RNA-based computing techniques have already been developed that can offer a complete set of Boolean logic functions and have been used, for example, to analyse cells and deliver molecular payloads. However, the computing potential of particle-based systems remains relatively unexplored. Here, we show that almost any type of nanoparticle or microparticle can be transformed into autonomous biocomputing structures that are capable of implementing a functionally complete set of Boolean logic gates (YES, NOT, AND and OR) and binding to a target as result of a computation. The logic-gating functionality is incorporated into self-assembled particle/biomolecule interfaces (demonstrated here with proteins) and the logic gating is achieved through input-induced disassembly of the structures. To illustrate the capabilities of the approach, we show that the structures can be used for logic-gated cell targeting and advanced immunoassays.

Original languageEnglish
Pages (from-to)716-722
Number of pages7
JournalNature Nanotechnology
Volume9
Issue number9
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

logic
Nanoparticles
Logic gates
Biomolecules
RNA
Robotics
DNA
Proteins
Sensors
nanoparticles
immunoassay
microparticles
robotics
cells
payloads
deoxyribonucleic acid
proteins
sensors

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Nikitin, M. P., Shipunova, V. O., Deyev, S. M., & Nikitin, P. I. (2014). Biocomputing based on particle disassembly. Nature Nanotechnology, 9(9), 716-722. https://doi.org/10.1038/nnano.2014.156

Biocomputing based on particle disassembly. / Nikitin, Maxim P.; Shipunova, Victoria O.; Deyev, Sergey M.; Nikitin, Petr I.

In: Nature Nanotechnology, Vol. 9, No. 9, 2014, p. 716-722.

Research output: Contribution to journalArticle

Nikitin, MP, Shipunova, VO, Deyev, SM & Nikitin, PI 2014, 'Biocomputing based on particle disassembly', Nature Nanotechnology, vol. 9, no. 9, pp. 716-722. https://doi.org/10.1038/nnano.2014.156
Nikitin, Maxim P. ; Shipunova, Victoria O. ; Deyev, Sergey M. ; Nikitin, Petr I. / Biocomputing based on particle disassembly. In: Nature Nanotechnology. 2014 ; Vol. 9, No. 9. pp. 716-722.
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