Abstract
Composites based on lactic acid oligomers, calcium hydrophosphate and hydroxyapatite synthesized under the action of microwave radiation were obtained in situ. The appearance of a new band associated with stretching vibrations of >C=O in spectra of the chloroform-insoluble fraction is indicative of the chemical interaction between lactic acid and hydroxyapatite. To determine whether a calcium phosphate layer can be formed on the surface of composite samples, biomimetic studies in a physiological SBF solution were carried out during 28 days at 37 C. It was found that all samples containing calcium phosphates promote active formation of a new calcium phosphate layer, whereas lactic acid oligomer in samples containing no inorganic component undergoes destruction in the SBF solution as a result of hydrolysis. The estimate of the resorption rate demonstrated that the solubility of calcium phosphates contained in the composites at 20 C in the physiological solution is 3-7 times that of pure hydroxyapatite.
| Original language | English |
|---|---|
| Pages (from-to) | 669-675 |
| Number of pages | 7 |
| Journal | Russian Journal of Applied Chemistry |
| Volume | 88 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 23 Apr 2015 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
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Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers. / Rasskazova, L. A.; Lytkina, D. N.; Shapovalova, Ye G.; Botvin, V. V.; Pozdnyakov, M. A.; Filimoshkin, A. G.; Korotchenko, N. M.; Kozik, V. V.
In: Russian Journal of Applied Chemistry, Vol. 88, No. 4, 23.04.2015, p. 669-675.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers
AU - Rasskazova, L. A.
AU - Lytkina, D. N.
AU - Shapovalova, Ye G.
AU - Botvin, V. V.
AU - Pozdnyakov, M. A.
AU - Filimoshkin, A. G.
AU - Korotchenko, N. M.
AU - Kozik, V. V.
PY - 2015/4/23
Y1 - 2015/4/23
N2 - Composites based on lactic acid oligomers, calcium hydrophosphate and hydroxyapatite synthesized under the action of microwave radiation were obtained in situ. The appearance of a new band associated with stretching vibrations of >C=O in spectra of the chloroform-insoluble fraction is indicative of the chemical interaction between lactic acid and hydroxyapatite. To determine whether a calcium phosphate layer can be formed on the surface of composite samples, biomimetic studies in a physiological SBF solution were carried out during 28 days at 37 C. It was found that all samples containing calcium phosphates promote active formation of a new calcium phosphate layer, whereas lactic acid oligomer in samples containing no inorganic component undergoes destruction in the SBF solution as a result of hydrolysis. The estimate of the resorption rate demonstrated that the solubility of calcium phosphates contained in the composites at 20 C in the physiological solution is 3-7 times that of pure hydroxyapatite.
AB - Composites based on lactic acid oligomers, calcium hydrophosphate and hydroxyapatite synthesized under the action of microwave radiation were obtained in situ. The appearance of a new band associated with stretching vibrations of >C=O in spectra of the chloroform-insoluble fraction is indicative of the chemical interaction between lactic acid and hydroxyapatite. To determine whether a calcium phosphate layer can be formed on the surface of composite samples, biomimetic studies in a physiological SBF solution were carried out during 28 days at 37 C. It was found that all samples containing calcium phosphates promote active formation of a new calcium phosphate layer, whereas lactic acid oligomer in samples containing no inorganic component undergoes destruction in the SBF solution as a result of hydrolysis. The estimate of the resorption rate demonstrated that the solubility of calcium phosphates contained in the composites at 20 C in the physiological solution is 3-7 times that of pure hydroxyapatite.
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U2 - 10.1134/S1070427215040205
DO - 10.1134/S1070427215040205
M3 - Article
VL - 88
SP - 669
EP - 675
JO - Russian Journal of Applied Chemistry
JF - Russian Journal of Applied Chemistry
SN - 1070-4272
IS - 4
ER -