Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers

L. A. Rasskazova, D. N. Lytkina, Ye G. Shapovalova, V. V. Botvin, M. A. Pozdnyakov, A. G. Filimoshkin, N. M. Korotchenko, V. V. Kozik

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Composites based on lactic acid oligomers, calcium hydrophosphate and hydroxyapatite synthesized under the action of microwave radiation were obtained in situ. The appearance of a new band associated with stretching vibrations of >C=O in spectra of the chloroform-insoluble fraction is indicative of the chemical interaction between lactic acid and hydroxyapatite. To determine whether a calcium phosphate layer can be formed on the surface of composite samples, biomimetic studies in a physiological SBF solution were carried out during 28 days at 37 C. It was found that all samples containing calcium phosphates promote active formation of a new calcium phosphate layer, whereas lactic acid oligomer in samples containing no inorganic component undergoes destruction in the SBF solution as a result of hydrolysis. The estimate of the resorption rate demonstrated that the solubility of calcium phosphates contained in the composites at 20 C in the physiological solution is 3-7 times that of pure hydroxyapatite.

    Original languageEnglish
    Pages (from-to)669-675
    Number of pages7
    JournalRussian Journal of Applied Chemistry
    Volume88
    Issue number4
    DOIs
    Publication statusPublished - 23 Apr 2015

    Fingerprint

    Calcium Phosphates
    Calcium phosphate
    Durapatite
    Lactic acid
    Oligomers
    Lactic Acid
    Hydroxyapatite
    Composite materials
    Biomimetics
    Chloroform
    Stretching
    Hydrolysis
    Chlorine compounds
    Solubility
    Microwaves
    Calcium
    calcium phosphate

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)

    Cite this

    Rasskazova, L. A., Lytkina, D. N., Shapovalova, Y. G., Botvin, V. V., Pozdnyakov, M. A., Filimoshkin, A. G., ... Kozik, V. V. (2015). Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers. Russian Journal of Applied Chemistry, 88(4), 669-675. https://doi.org/10.1134/S1070427215040205

    Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers. / Rasskazova, L. A.; Lytkina, D. N.; Shapovalova, Ye G.; Botvin, V. V.; Pozdnyakov, M. A.; Filimoshkin, A. G.; Korotchenko, N. M.; Kozik, V. V.

    In: Russian Journal of Applied Chemistry, Vol. 88, No. 4, 23.04.2015, p. 669-675.

    Research output: Contribution to journalArticle

    Rasskazova, LA, Lytkina, DN, Shapovalova, YG, Botvin, VV, Pozdnyakov, MA, Filimoshkin, AG, Korotchenko, NM & Kozik, VV 2015, 'Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers', Russian Journal of Applied Chemistry, vol. 88, no. 4, pp. 669-675. https://doi.org/10.1134/S1070427215040205
    Rasskazova LA, Lytkina DN, Shapovalova YG, Botvin VV, Pozdnyakov MA, Filimoshkin AG et al. Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers. Russian Journal of Applied Chemistry. 2015 Apr 23;88(4):669-675. https://doi.org/10.1134/S1070427215040205
    Rasskazova, L. A. ; Lytkina, D. N. ; Shapovalova, Ye G. ; Botvin, V. V. ; Pozdnyakov, M. A. ; Filimoshkin, A. G. ; Korotchenko, N. M. ; Kozik, V. V. / Bioactive composites produced in situ on the basis of calcium phosphates and lactic acid oligomers. In: Russian Journal of Applied Chemistry. 2015 ; Vol. 88, No. 4. pp. 669-675.
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