Basic and practical concepts of radiopharmaceutical purification methods

Sajjad Molavipordanjani, Vladimir Tolmachev, Seyed Jalal Hosseinimehr

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The presence of radiochemical impurities in a radiopharmaceutical contributes to an unnecessary radiation burden for the patients or to an undesirable high radioactivity background, which reduces the imaging contrast or therapeutic efficacy. Therefore, if the radiolabeling process results in unsatisfactory radiochemical purity, a purification step is unavoidable. A successful purification process requires a profound knowledge about the radiopharmaceuticals of interest ranging from structural features to susceptibility to different conditions. Most radiopharmaceutical purification methods are based on solid-phase extraction (SPE), high-performance liquid chromatography (HPLC), size exclusion chromatography (SEC), ion-exchange chromatography (IEC), and liquid–liquid extraction (LLE). Here, we discuss the basic and applied concepts of these purifications methods as well as their advantages and limitations.

Original languageEnglish
Pages (from-to)315-324
Number of pages10
JournalDrug Discovery Today
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 2019
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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