Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides

T. F. Mikhailovskaya, S. F. Vasilevsky

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalRussian Chemical Bulletin
Volume59
Issue number3
DOIs
Publication statusPublished - 1 Mar 2010
Externally publishedYes

Fingerprint

hydrazine
Benzoates

Keywords

  • Cross-coupling
  • Heterocyclization
  • Isoin- dolinones
  • O-alkynylbenzhydrazides
  • Phthalazinones
  • Recyclization

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides. / Mikhailovskaya, T. F.; Vasilevsky, S. F.

In: Russian Chemical Bulletin, Vol. 59, No. 3, 01.03.2010, p. 632-636.

Research output: Contribution to journal › Article

Mikhailovskaya, TF & Vasilevsky, SF 2010, 'Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides', Russian Chemical Bulletin, vol. 59, no. 3, pp. 632-636. https://doi.org/10.1007/s11172-010-0133-0
Mikhailovskaya TF, Vasilevsky SF. Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides. Russian Chemical Bulletin. 2010 Mar 1;59(3):632-636. https://doi.org/10.1007/s11172-010-0133-0
Mikhailovskaya, T. F. ; Vasilevsky, S. F. / Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides. In: Russian Chemical Bulletin. 2010 ; Vol. 59, No. 3. pp. 632-636.
@article{3724e4f2f7b3413ea451fbb523b48909,
title = "Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides",
abstract = "The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.",
keywords = "Cross-coupling, Heterocyclization, Isoin- dolinones, O-alkynylbenzhydrazides, Phthalazinones, Recyclization",
author = "Mikhailovskaya, {T. F.} and Vasilevsky, {S. F.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1007/s11172-010-0133-0",
language = "English",
volume = "59",
pages = "632--636",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides

AU - Mikhailovskaya, T. F.

AU - Vasilevsky, S. F.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.

AB - The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.

KW - Cross-coupling

KW - Heterocyclization

KW - Isoin- dolinones

KW - O-alkynylbenzhydrazides

KW - Phthalazinones

KW - Recyclization

UR - http://www.scopus.com/inward/record.url?scp=78649762190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649762190&partnerID=8YFLogxK

U2 - 10.1007/s11172-010-0133-0

DO - 10.1007/s11172-010-0133-0

M3 - Article

AN - SCOPUS:78649762190

VL - 59

SP - 632

EP - 636

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 3

ER -

Access to Document