Abstract
The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.
| Original language | English |
|---|---|
| Pages (from-to) | 632-636 |
| Number of pages | 5 |
| Journal | Russian Chemical Bulletin |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2010 |
| Externally published | Yes |
Keywords
- Cross-coupling
- Heterocyclization
- Isoin- dolinones
- O-alkynylbenzhydrazides
- Phthalazinones
- Recyclization
ASJC Scopus subject areas
- Chemistry(all)
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Cite this
Mikhailovskaya, T. F., & Vasilevsky, S. F. (2010). Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides. Russian Chemical Bulletin, 59(3), 632-636. https://doi.org/10.1007/s11172-010-0133-0