Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides

T. F. Mikhailovskaya, S. F. Vasilevsky

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1- ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin- 1-ones.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalRussian Chemical Bulletin
Issue number3
Publication statusPublished - 1 Mar 2010
Externally publishedYes


  • Cross-coupling
  • Heterocyclization
  • Isoin- dolinones
  • O-alkynylbenzhydrazides
  • Phthalazinones
  • Recyclization

ASJC Scopus subject areas

  • Chemistry(all)

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