Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids

S. F. Vasilevskii, T. F. Mikhailovskaya, A. A. Stepanov, V. I. Mamatyuk, D. S. Fadeev

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sonogashira alkynylation of methyl 2-iodobenzoate with terminal acetylenes gave a series of methyl 2-(alk-1-yn-1-yl)benzoates which reacted with hydroxylamine in boiling methanol to produce five- or six-membered N-hydroxy lactams, 3-R-methylidene-2-hydroxy-2,3-dihydroisoindol-1-ones or 3-R-isoquinolin-1(2H)-ones, depending on the acetylenic substituent nature.

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalRussian Journal of Organic Chemistry
Volume50
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids'. Together they form a unique fingerprint.

  • Cite this