Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids

S. F. Vasilevskii, T. F. Mikhailovskaya, A. A. Stepanov, V. I. Mamatyuk, D. S. Fadeev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Sonogashira alkynylation of methyl 2-iodobenzoate with terminal acetylenes gave a series of methyl 2-(alk-1-yn-1-yl)benzoates which reacted with hydroxylamine in boiling methanol to produce five- or six-membered N-hydroxy lactams, 3-R-methylidene-2-hydroxy-2,3-dihydroisoindol-1-ones or 3-R-isoquinolin-1(2H)-ones, depending on the acetylenic substituent nature.

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalRussian Journal of Organic Chemistry
Issue number4
Publication statusPublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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